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Description
IL-16(130aa) Protein, HumanProduct Specification Species Human Synonyms Pro interleukin 16; Interleukin 16, IL 16, Lymphocyte chemoattractant factor (LCF) Accession Q14005 Amino Acid Sequence Met1203 Ser1332 Expression System E. coli Molecular Weight 18 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 300mM NaCl pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml
Product Specification
| Species | Human |
| Synonyms | Pro-interleukin-16; Interleukin-16, IL-16, Lymphocyte chemoattractant factor (LCF) |
| Accession | Q14005 |
| Amino Acid Sequence | Met1203-Ser1332 |
| Expression System | E.coli |
| Molecular Weight | 18 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 300mM NaCl pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Proc Natl Acad Sci U S A. 1994 May 24;91(11):5109-13. |
Background
Interleukin-16 (IL-16) is a cytokine that plays a key role in regulating immune responses and inflammation. It is produced by various immune cells, including CD4+ T cells, mast cells, and eosinophils. IL-16 functions as a chemoattractant for CD4+ T cells, promoting their migration to sites of inflammation. Additionally, IL-16 can modulate the activation and proliferation of CD4+ T cells, as well as other immune cells, through interactions with its receptor, CD4. This cytokine is involved in the pathogenesis of various inflammatory conditions, autoimmune diseases, and cancer.
IL-16 exists in two isoforms: the full-length 130 amino acid (130aa) isoform and a shorter 121 amino acid (121aa) isoform. The 130aa isoform is the canonical form of IL-16 and is known for its chemoattractant and immunomodulatory functions. On the other hand, the 121aa isoform lacks the CD4-binding domain present in the 130aa isoform, resulting in reduced CD4-binding capacity and altered biological activity. The 121aa isoform may exhibit different chemotactic properties and signaling capabilities compared to the full-length 130aa isoform.
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