SKU: 78269330230

PILRα His Tag Protein, Human

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Description

PILRα His Tag Protein, HumanProduct Specification Species Human Synonyms PILR, PILRA, FDF03, AV021745 Accession Q9UKJ1 1 Amino Acid Sequence Gln20 Thr196, with C terminal 8*His QPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETGGGSHHHHHHHH Expression System HEK293 Molecular Weight 41 47kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation

Product Specification


Species Human
Synonyms PILRα, PILRA, FDF03, AV021745
Accession Q9UKJ1-1
Amino Acid Sequence Gln20-Thr196, with C-terminal 8*His QPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETGGGSHHHHHHHH
Expression System HEK293
Molecular Weight 41-47kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Shiratori I. et al. (2004) Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 199: 525-533.

2、Satoh T. et al. (2008) PILRα is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell. 132: 935-944.

3、Wang J. et al. (2013) Neutrophilin filtration during inflammation is regulated by PILRαvia modulation ofintegrin activation. Nat Immunol. 14: 34-40.

4、Sun Y. et al. (2014) PILRα negatively regulates mouse inflammatoryarthritis. J Immunol. 193: 860-870.

Background

Paired immunoglobulin-like type 2 receptor α (PILRα) is an inhibitory receptor that is mainly expressed on macrophages, dendritic cells and granulocytes, and negatively regulates neutrophil infiltration during inflammation. PILRα containing two immunoreceptor tyrosine-based inhibitory motifs in the intracellular domain, which recruit Src homology region 2 domain-containing phosphatase (SHP)-1 and -2. Reported that PILRα associates with several ligands, including CD99, PILR-associating neural protein, neuronal differentiation proliferation factor-1, and collectin-12, and PILRα plays an important role in viral infections. Neutrophil recruitment in inflammatory responses is regulated by PILRα via modulation of integrin activation. Furthermore, negative regulation of inflammatory arthritis by PILRα has been reported.
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SKU: 78269330230

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Amy Carreon
Boise, US
★★★★★ 5
Love the color!
Size: 9.5, Color: Dark Tan
Boyfriend loved them, nice and rich in color. He thought they were comfy and the style was accurate.
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Reviewed in the United States on May 31, 2026
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mike espelund
Grantham, US
★★★★★ 5
fits well
Size: 9.5, Color: Black
great shoes suprisingly well made
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Reviewed in the United States on May 13, 2026
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Amazon Customer
Lowell, US
★★★★★ 5
Good design
Size: 10.5, Color: Cognac, Size: 10.5, Color: Cognac
Nice design and perfect craftsmanship. For the shoe material, the quality is ok.
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Reviewed in the United States on April 11, 2026
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Marina Eshak
Chelsea, US
★★★★★ 3
Light but average
Size: 10.5, Color: Black
Three stars. These are very lightweight and seem fine for the price, but the leather felt a bit too thin for what I was looking for. I didn’t even end up trying them on because they just didn’t feel like they would hold up long term. They’re not bad if you need something inexpensive for occasional wear, but I wanted something that would last. It felt like they might scratch easily, so I decided to return these and go with a more expensive option instead.
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Reviewed in the United States on February 2, 2026
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Remo Garrovillo
New York, US
★★★★★ 5
Good quality
Size: 9, Color: Cognac
Good quality and fit is true to size
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Reviewed in the United States on January 19, 2026

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