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Description
Biotinylated BAFFR/TNFRSF13C Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms BROMIX,CD268,CVID4,prolixin,BAFF R,BR3 Accession Q96RJ3 1 Amino Acid Sequence Ser7 Ala71 with hIgG1 Fc&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 40 50kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Biotin Tag Avi Tag, Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | BROMIX,CD268,CVID4,prolixin,BAFF-R,BR3 |
| Accession | Q96RJ3-1 |
| Amino Acid Sequence | Ser7-Ala71 with hIgG1 Fc&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 40-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Aharon A, Birnboim-Perach R, Grotto O, Amir A, Diadko D, Beltran N, Nahary L, Benhar I. Evaluating the Therapeutic Efficacy of an Anti-BAFF Receptor Antibody Using a Rheumatoid Arthritis Mouse Model. Antibodies (Basel). 2025 Oct 20;14(4):90. |
Background
BAFF receptor (BAFF-R/TNFRSF13C, CD268), a member of the tumor necrosis factor receptor superfamily, is a type III transmembrane protein that binds its ligand BAFF as a trimer. Via adaptor proteins it transduces signals essential for B-cell survival, development and the size of the peripheral B-cell pool, thereby tuning both innate and adaptive immunity. Elevated BAFF/BAFF-R levels in human serum or tissues prolong the lifespan of autoreactive B cells and are closely linked to the onset and activity of autoimmune diseases such as systemic lupus erythematosus, making BAFF-R a key diagnostic biomarker and the central target of therapeutics including BAFF or BAFF-R inhibitors.
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