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Description
NaPi2b/SLC34A2 Recombinant Rabbit mAb (SDT-R229)Product Specification Host Rabbit Antigen NaPi2b SLC34A2 Synonyms Sodium dependent phosphate transport protein 2B; Sodium phosphate transport protein 2B; Na(+) dependent phosphate cotransporter 2B; NaPi3b; Sodium phosphate cotransporter 2B (Na(+) Pi cotransporter 2B; NaPi 2b); Solute carrier family 34 member 2 Location Apical cell membrane Accession O95436 Clone Number SDT R229 Antibody Type Recombinant mAb Isotype IgG Application ICFCM, IHC P, ICC,
Product Specification
| Host | Rabbit |
| Antigen | NaPi2b/SLC34A2 |
| Synonyms | Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B (Na(+)/Pi cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2 |
| Location | Apical cell membrane |
| Accession | O95436 |
| Clone Number | SDT-R229 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICFCM, IHC-P, ICC, WB, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| IF | 1:500 | |
| ICFCM | 1:500 |
Background
Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene. NaPi2b is a cell surface sodiumdependent phosphate transporter that regulates phosphate homeostasis under normal physiological conditions and is a lineage marker that is expressed in select cancers, including ovarian, lung, thyroid, and breast cancers, with limited expression in normal tissues. Based on its increased expression in ovarian tumors, NaPi2b is a promising candidate to be studied as a biomarker for treatment and patient selection in ovarian cancer. In preclinical studies, the use of antibodies against NaPi2b showed that this protein can be exploited for tumor mapping and therapeutic targeting.
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