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Description
OTX2 Recombinant Rabbit mAb (S-2095-8)Product Specification Host Rabbit Antigen OTX2 Synonyms Homeobox protein OTX2; Orthodenticle homolog 2 Immunogen Synthetic Peptide Location Nucleus Accession P32243 Clone Number S 2095 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms Positive Sample NTERA 2, normal mouse E14 foetal brain Predicted Reactivity Ys, Zf Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | OTX2 |
| Synonyms | Homeobox protein OTX2; Orthodenticle homolog 2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P32243 |
| Clone Number | S-2095-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms |
| Positive Sample | NTERA-2, normal mouse E14 foetal brain |
| Predicted Reactivity | Ys, Zf |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000 | Hu, Ms |
| IHC-P | 1:5000 | Ms |
| IF | 1:500 | Ms |
Background
OTX2 protein, also known as orthodenticle homeobox 2, is a transcription factor encoded by the OTX2 gene and belongs to the homeobox-containing gene family. It plays crucial roles in various developmental processes, particularly in the formation and function of the central nervous system. OTX2 is highly expressed in the brain, including regions such as the cerebral cortex and cerebellum. This protein is also involved in the development of the retina, where it is expressed in photoreceptors and bipolar cells. Additionally, OTX2 has been implicated in non-cell-autonomous activities, meaning it can influence neighboring cells through diffusion and interaction. Abnormalities in the OTX2 gene have been associated with conditions like microphthalmia and pituitary hormone deficiency. Recent studies also suggest a potential link between OTX2 and major depressive disorders.
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