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Description
Siglec-7/CD328 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CDw328, AIRM 1, Adhesion inhibitory receptor molecule 1, D siglec, QA79 membrane protein, CD328, siglec 7 Accession Q9Y286 1 Amino Acid Sequence Gln19 Leu353, with C hIgG Fc Expression System HEK293 Molecular Weight 75 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, pH7. 4 Reconstitution
Product Specification
| Species | Human |
| Synonyms | CDw328, AIRM-1, Adhesion inhibitory receptor molecule 1, D-siglec, QA79 membrane protein, CD328, siglec-7 |
| Accession | Q9Y286-1 |
| Amino Acid Sequence | Gln19-Leu353, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 75-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Crocker, P.R. et al. (1998) Glycobiology 8:v. Crocker, P.R. and A. Varki (2001) Trends Immunol. 22:337. Crocker, P.R. and A. Varki (2001) Immunology 103:137. Angata, T. et al. (2002) J. Biol. Chem. 277:24466. |
Background
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells.
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