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Description
SLFN11 Recombinant Mouse mAb (S-1565-283)Product Specification Host Mouse Antigen SLFN11 Synonyms Schlafen family member 11 Immunogen Synthetic Peptide Location Nucleus Accession Q7Z7L1 Clone Number S 1565 283 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu Positive Sample SK OV 3, DU 145, A172, Jurkat, human tonsil, human esophageal carcinoma, human lung squamous cancer, human stomach Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Mouse |
| Antigen | SLFN11 |
| Synonyms | Schlafen family member 11 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q7Z7L1 |
| Clone Number | S-1565-283 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | SK-OV-3, DU 145, A172, Jurkat, human tonsil, human esophageal carcinoma, human lung squamous cancer, human stomach |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000 | Hu |
| IHC-P | 1:400 | Hu |
Background
Schlafen 11 (SLFN11) is a protein encoded by the SLFN11 gene, belonging to the interferon-inducible Schlafen family. It is primarily known for its roles in antiviral defense, regulation of cellular replication, and its emerging significance in cancer biology. SLFN11 acts as an antiviral restriction factor by degrading specific transfer RNAs (tRNAs) through its endoribonuclease activity, thereby inhibiting viral protein synthesis, particularly in HIV-1 infections. In cancer, SLFN11 is associated with cellular sensitivity to DNA-damaging agents, including topoisomerase inhibitors, alkylating agents, and PARP inhibitors. High expression of SLFN11 correlates with increased sensitivity to these treatments, while its downregulation is linked to drug resistance and poor prognosis in various cancers, such as small cell lung cancer. Additionally, SLFN11 can induce apoptosis through ribosome stalling and the activation of innate immune responses when recognizing specific ssDNA motifs.
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