SKU: 68727047877

Siglec-5 Fc Chimera Protein, Human

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Description

Siglec-5 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Sialic acid binding Ig like lectin 5, CD33 antigen like 2, SIGLEC5, CD33L2, OBBP2 Accession O15389 Amino Acid Sequence Glu17 Thr434, with C terminal Human IgG1 Fc

Product Specification


Species Human
Synonyms Sialic acid-binding Ig-like lectin 5, CD33 antigen-like 2, SIGLEC5, CD33L2, OBBP2
Accession O15389
Amino Acid Sequence

Glu17-Thr434, with C-terminal Human IgG1 Fc EKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System HEK293
Molecular Weight

93-102kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1.Powell, L.D. et al. (1995) J. Biol. Chem. 270:14243. 2.May, A.R. et al. (1998) Mol. Cell 1998. 1:719.

Background

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are cell surface receptors of the I-type lectin family that are expressed on innate immune cells and bind to sialylated and non-sialylated ligands. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. Siglec-5 is Biased expression in bone marrow (RPKM 12.5), spleen (RPKM 10.6) and 12 other tissues. Siglec-5 is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

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SKU: 68727047877

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4.6 ★★★★★
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A.
Cuba, US
★★★★★ 4
Why do black people . . .
Format: Hardcover
I purchased this book because I had many questions I wanted answered. Most of them were questions of "Why?". My biggest question was why we as black people have so many unhealthy habits in how we treat each other. As a young African American male who was raised by his mother in a predominantly white suburban area, I wanted to know why, when I encountered other black youth in more urban areas, they would tell me I "talk white." What is "talking white?" Basically, talking white means I was talking like I have an education. Why do so many members of the black community (those without an education) reject me for valuing education? Why is it that when one black person fidns a way out of the ghetto, it seems the whole neighborhood, church included, condems that person for leaving "his/her people" and wanting to live in the suburbs with the whites? Why don't we support one-another in this society that has always held us from achieving our full potential? I wanted to learn why we seem to have no clue of who we are, and so many of us, young and old, strive to "prove" we are "black enough." So talking a certain way makes us black? Or is it eating certain foods that makes us "black"? Listening to only certain kinds of music? We lack a firm sense of cultural identity. We take rebellious pride in being at the bottom, and equate success with "whiteness." We denounce the achievements of any black person and ostracize him from the community. We work to pressure our own to stay at the bottom. In this very interesting book, the author, Dr. Joy Degruy Leary, proposes a number of explanations for why the African American community has developed these and other unhealthy cultural habits. Leary examines this very real "crabs in the barrel" mentality, as well as many other self-destructive habits which plague the black community. Leary establishes a diagnoses, and calls it Post-Traumatic Slave Syndrome. Leary presents a very strong argument that the behaviors are all symptoms that have been passed down through the generations of African American people from the dawn of the trans-atlantic slave trade to today. Leary uses her own observations to support her theory of Post-Traumatic Slave Syndrome. This book is a very thoughtful read. The reason I give this work only four stars is because I truly feel that Leary's argument would have been much more affirmed and effective if she had included a visual timeline to help the reader to better understand the timeframes and chain of events in history discussed in the book. The argument also would have been more effective if the author spent more time on each point. At times it seems she's just getting started before summarizing all that was just said and moving on. Scholarly sources are cited and research is used, but the book does not explore any one study or statistic in great depth. It is a fast read.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 16, 2012
E
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ez2laf
Grantham, US
★★★★★ 5
America's Biggest Lie
African Americans have been brutalized beyond imagination. Then told that they were the ones that were less than human. It boggles the mind. The whites beat, burned, skinned, lynched, mutilated and murdered African Americans at will. And these same whites believe (to this day) that this is their god given right. Even worst was the emotional and intellectual scars left from the lies that were told. If I didn't see the consequence of this everyday, I would think someone was lying to me: Some kind of Cosmic joke. The white criminals are the heroes and the African victims are the villains. This cannot actually be real. But it is. Whites stripped the Africans of their names, religions, dignity, culture and their humanity. Then called them less than human. This slight of hand is beyond comprehension. The funniest part is when I hear Whites yell to blacks "go back to Africa." This is tantamount to kidnapping someone, tying them up, putting them in your basement then yelling at them to get out of your house. Insane. This has been going on for 400 years. Wow. And America thinks it the moral leader of the free world. I have to pinch myself. This has to be a dream.... or a nightmare. The book opened my eyes.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 18, 2017
S
Verified Purchase
Sherri
Battle Creek, US
★★★★★ 5
I have to step up as a parent..
Format: Hardcover
The book is a little bigger than what I realized. I must not have paid a attention to that because I did a quick buy. But thats not a bad thing it is a really nice coffee table book the pictures are great. I skimmed the book and it has some wonderful information. I wanted to have something to catch the attention of my GenAlpha son so he can learn about our history the school did a horrible job this year with learning Black history which is American history. Plan to get the study guide to help me talk about this with my son. Given the time we are living in I need to do better with informing and guiding him with facts. Because of my school and parents I learned a some of this growing up but the schools are barely teaching anything past MLK, Malcolm X or Harriet Tubman!
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Reviewed in the United States on April 29, 2026
B
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2BMSALG😎😎😎
Pawtucket, US
★★★★★ 5
Must have👏🏾👏🏾👏🏾👏🏾
Format: Hardcover
Excellent hardcover and a must to a collection of history that many may not know. Take the journey that many will never understand 👏🏾💜🙌🏾
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Reviewed in the United States on April 28, 2026
D
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Dglana
West Palm Beach, US
★★★★★ 5
a beautiful important history book
Format: Hardcover
What an amazing book! This book is the version with incredible photos as part of the history story. I couldn't believe how vivid this was when I opened up the book. I'd been wanting the book for a while, because so little is told of the enslaved people's history in this country. It is important for us to understand our past, and without books like this one we do not have the full story. Thank you to the authors who put together this beautiful book.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 22, 2025

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