Pay in installments of $69.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
GUCY2C His Tag Protein, HumanProduct Specification Species Human Synonyms GUCY2C, GC C, STAR, DIAR6, GUC2C, MECIL, MUCIL Accession P25092 Amino Acid Sequence Ser24 Gln430, with C terminal 8*His
Product Specification
| Species | Human |
| Synonyms | GUCY2C, GC-C, STAR, DIAR6, GUC2C, MECIL, MUCIL |
| Accession | P25092 |
| Amino Acid Sequence | Ser24-Gln430, with C-terminal 8*His SQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 90-115kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Blomain E S. et al. (2016) Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer. Molecular Pharmacology. 90(3): 199-204. |
Background
Guanylyl cyclase C (GUCY2C) is a membrane-bound receptor that produces the second messenger cGMP following activation by its hormone ligands guanylin or uroguanylin, regulating intestinal homeostasis, tumorigenesis, and obesity. In turn, cGMP signaling regulates homeostatic processes in intestine that are canonically disrupted in cancer, including maintenance of DNA integrity and genomic stability. GUCY2C is expressed mostly on the apical surface of intestinal cells but also in the kidney, airway epithelium, perinatal liver, stomach, brain, adrenal glands, and reproductive tissues. Analogous to other rGCs, the primary sequence of GUCY2C reveals a multidomain architecture. Residues 1-23 comprise a putative signal peptide that directs the receptor to the cell surface. This is followed by the ECD (residues 24-430). The intracellular region has a short juxta-membrane domain (residues 455-489) which is followed by a kinase-homology domain (KHD) (residues 490-735), the linker region (residues 736-810), the guanylyl cyclase domain (GCD) (residues 811-1,010), and a C-terminal domain (CTD) (residues 1,011-1,073). Guanylyl cyclase C receptor (GUCY2C) and its hormones, uroguanylin and guanylin, have emerged as a key signaling axis opposing mutations driving intestinal tumorigenesis.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy