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Description
PSEN2 Recombinant Rabbit mAb (S-2084-14)Product Specification Host Rabbit Antigen PSEN2 Synonyms Presenilin 2; PS 2; AD3LP; AD5; E5 1; STM 2; AD4; PS2; PSNL2; STM2 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P49810 Clone Number S 2084 14 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, HeLa Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | PSEN2 |
| Synonyms | Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2; AD4; PS2; PSNL2; STM2 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P49810 |
| Clone Number | S-2084-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | SH-SY5Y, HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
PSEN2, which stands for presenilin 2, is a protein encoded by the PSEN2 gene. It is an integral membrane protein that is a key component of the gamma-secretase enzyme complex. This complex is involved in the cleavage of amyloid precursor protein (APP), which generates amyloid-beta peptides. Mutations in the PSEN2 gene have been linked to early-onset familial Alzheimer's disease, as these mutations can lead to an increased production of amyloid-beta 42, a peptide that is more prone to aggregate and form plaques in the brain. PSEN2 is primarily located in the endoplasmic reticulum and Golgi apparatus, and it plays a crucial role in regulating cellular processes such as protein trafficking and signal transduction.
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