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Description
SLC31A1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SLC31A1 Synonyms High affinity copper uptake protein 1; Copper transporter 1 (hCTR1); Solute carrier family 31 member 1; COPT1; CTR1; SLC31A1 Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession O15431 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Caco 2, Ramos, HepG2, HT 29, mouse brain, rat brain Predicted Reactivity Or, Pg Purification
Product Specification
| Host | Rabbit |
| Antigen | SLC31A1 |
| Synonyms | High affinity copper uptake protein 1; Copper transporter 1 (hCTR1); Solute carrier family 31 member 1; COPT1; CTR1; SLC31A1 |
| Immunogen | Synthetic Peptide |
| Location | Endosome, Cell membrane |
| Accession | O15431 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, Ramos, HepG2, HT-29, mouse brain, rat brain |
| Predicted Reactivity | Or, Pg |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | Hu, Ms, Rt |
Background
SLC31A1 (also known as CTR1) is a high-affinity, plasma-membrane copper importer that drives cuprous ion (Cu⁺) uptake by forming a homotrimeric channel, binds blood Cu²⁺-albumin at its N-terminal domain to initiate reduction and vectorial transport, hands Cu⁺ to the chaperone ATOX1 via its C-terminal HCH motif, is transcriptionally repressed by Cu-loaded Sp1 yet induced by hypoxia through HIF-2α/EPAS1, undergoes rapid endocytosis and degradation when intracellular copper rises, doubles as a saturable gate for cisplatin, silver and cadmium uptake, triggers cuproptosis when over-expressed, and in endothelial cells acts as a redox sensor that transmits VEGF-generated ROS through Cys-189 sulfenylation to form a disulfide-linked SLC31A1–KDR complex whose co-internalization sustains VEGFR2 signaling and angiogenesis independent of copper transport.
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