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Description
Phospho-Lck (Tyr394) Recombinant Rabbit mAb (S-1957-74)Product Specification Host Rabbit Antigen Phospho Lck (Tyr394) Synonyms Tyrosine protein kinase Lck; Leukocyte C terminal Src kinase (LSK); Lymphocyte cell specific protein tyrosine kinase; Protein YT16; Proto oncogene Lck; T cell specific protein tyrosine kinase; p56 LCK; LCK Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P06239 Clone Number S 1957 74 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Lck (Tyr394) |
| Synonyms | Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase (LSK); Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK; LCK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P06239 |
| Clone Number | S-1957-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Ck, CyMk, Dg, Pg, Xe, Zf |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:5000 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
Phospho-Lck (Tyr394) protein is a phosphorylated form of the Lck protein at tyrosine residue 394. Lck, or lymphocyte-specific protein tyrosine kinase, is a non-receptor tyrosine kinase that plays a crucial role in the early stages of T-cell activation. When phosphorylated at Tyr394, Lck becomes fully activated, enabling it to initiate downstream signaling cascades. This phosphorylation event is essential for the proper functioning of the immune system, as it helps in the transmission of signals from the T-cell receptor to intracellular effectors, ultimately leading to T-cell proliferation and differentiation. Abnormal regulation of Phospho-Lck (Tyr394) has been implicated in various immune disorders, making it an important target for therapeutic interventions.
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