SKU: 61414280144

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)

Sale price$135.00 Regular price$150.00
Save 10%

Pay in installments of $37.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 28 - Aug 2

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)Product Specification Host Mouse Antigen TIGIT Synonyms T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing protein 9; V set and transmembrane domain containing protein 3; VSIG9; VSTM3 Location Cell membrane, Synapse Accession Q495A1 Clone Number S R730 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer

Product Specification


Host Mouse
Antigen TIGIT
Synonyms T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3
Location Cell membrane, Synapse
Accession Q495A1
Clone Number S-R730
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Purification Protein A
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5 μl per million cells in 100μl volume

Background

TIGIT (T cell immunoglobulin and ITIM domain) is an inhibitory receptor expressed on lymphocytes, including natural killer (NK) cells and various subsets of T cells such as CD4+ T cells, CD8+ T cells, and regulatory T cells. It was discovered in 2009 through genome-wide analysis aiming to identify proteins containing domain structures typical for immunomodulatory receptors. TIGIT consists of one extracellular immunoglobulin variable domain, a type I transmembrane domain, and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. Its main ligand is CD155, also known as poliovirus receptor (PVR), but it can also bind to CD112 and CD113 with lower affinity. TIGIT plays a significant role in down-regulating T cell and NK cell functions by interacting with these ligands expressed on antigen-presenting cells or tumor cells. This interaction inhibits immune cell responses at multiple steps of the cancer-immunity cycle, such as impairing T cell priming by dendritic cells, preventing tumor cell killing by NK cells and cytotoxic T cells, and enhancing the immune suppressive activity of regulatory T cells. Therefore, TIGIT has emerged as a major target in cancer immunotherapy. Several monoclonal antibodies that block the inhibitory activity of human TIGIT have been developed, and clinical trials are ongoing to investigate TIGIT blockade as a monotherapy or in combination with anti-PD1/PD-L1 antibodies for the treatment of patients with advanced solid malignancies.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 61414280144

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.3 ★★★★★
Based on 21 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
K
Verified Purchase
Kindle Customer
Phoenix, US
★★★★★ 5
Sun protection that works!
Size: 4 Fl Oz (Pack of 2), Style: SPF 100/Lotion
My bf is very pale and this sunscreen covers him and prevents burns. Great price for all of that SPF protection’
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2026
S
Verified Purchase
Sidd
Charlottesville, US
★★★★★ 5
Good. Non greasy
Size: 4 Fl Oz (Pack of 2), Style: SPF 100/Lotion
These are very good and give good protection against the sun. Not greasy as well..
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 17, 2026
V
Verified Purchase
VICTOR
Lowell, US
★★★★★ 5
Good sunblock
Size: 4 Fl Oz (Pack of 2), Style: SPF 100/Lotion
Easy to carry sunblock Does its job well
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 30, 2026
S
Verified Purchase
screw missing
Waukegan, US
★★★★★ 5
Sun saver.
Size: 4 Fl Oz (Pack of 2), Style: SPF 100/Lotion
Love this at the pool yard work, fishing. Any place you need protection from the sun.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 2, 2026
J
Verified Purchase
Julian Valencia
San Leandro, US
★★★★★ 5
Must have for summer
Size: 4 Fl Oz (Pack of 2), Style: SPF 100/Lotion
Love how it protects my skin!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2026

recommand products