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Description
Phospho-α-Synuclein (Ser129) Recombinant Rabbit mAb, PBS Only (SDT-3397)Product Specification Host Rabbit Antigen Phospho Synuclein (Ser129) Synonyms Alpha synuclein; Non A beta component of AD amyloid; Non A4 component of amyloid precursor (NACP); NACP; PARK1; SNCA Location Cytoplasm, Nucleus, Secreted, Synapse Accession P37840 Clone Number SDT 3397 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Phospho-α-Synuclein (Ser129) |
| Synonyms | Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor (NACP); NACP; PARK1; SNCA |
| Location | Cytoplasm, Nucleus, Secreted, Synapse |
| Accession | P37840 |
| Clone Number | SDT-3397 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Ms, Rt |
Background
Phospho-α-Synuclein (Ser129) is the pathognomonic form of α-synuclein in which the serine at position 129 is stoichiometrically phosphorylated, a post-translational switch that converts the natively unfolded presynaptic protein into a sticky, aggregation-prone seed capable of nucleating Lewy bodies and Lewy neurites, propagating trans-synaptically between neurons, activating microglia and complement, and serving as the most specific biochemical correlate of dopaminergic neurodegeneration in Parkinson’s disease and dementia with Lewy bodies.
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