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Description
TLR2 Recombinant Rabbit mAb (S-2585-57)Product Specification Host Rabbit Antigen TLR2 Synonyms Toll like receptor 2; Toll interleukin 1 receptor like protein 4; TIL4; CD282 Immunogen Recombinant Protein Accession O60603 Clone Number S 2585 57 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample THP 1, RAW264. 7, HepG2, mouse spleen, rat spleen Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | TLR2 |
| Synonyms | Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; TIL4; CD282 |
| Immunogen | Recombinant Protein |
| Accession | O60603 |
| Clone Number | S-2585-57 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | THP-1, RAW264.7, HepG2, mouse spleen, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu |
| ICC | 1:100 | Hu |
Background
TLR2, also known as CD282, is an approximately 89-kDa type I transmembrane receptor of the Toll-like receptor family that plays a pivotal role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) such as bacterial lipoproteins and cell wall components; it cooperates with co-receptors like LY96 and forms heterodimers with TLR1 or TLR6 to activate the MYD88- and TRAF6-dependent signaling pathway, leading to NF-κB activation, cytokine secretion, and inflammatory responses, while being abundantly expressed in peripheral blood leukocytes, especially monocytes, and involved in host defense against Gram-positive bacteria and yeast.
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