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Description
Human CD45, His tagProduct Specification Species Human Synonyms Receptor type tyrosine protein phosphatase C, Leukocyte common antigen (L CA), T200, PTPRC Accession P08575 Amino Acid Sequence Protein sequence(P08575, Gln26 Lys577, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen (L-CA), T200, PTPRC |
| Accession | P08575 |
| Amino Acid Sequence | Protein sequence(P08575, Gln26-Lys577, with C-10*His) QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:62.4kDa Actual:100-150kDa |
| Purity | ＞95% by SDS-PAGE |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling. CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells.
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4.6 ★★★★★
Based on 25 reviews
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Product Reviews
★★★★★ 3
Hard to assemble
Color: Grey
This is extremely hard to put together, but once its together it is pretty good. You will need to secure it to something. It falls over.
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Reviewed in the United States on March 6, 2026
★★★★★ 5
Works well!
Color: Grey
Works great!
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Reviewed in the United States on May 4, 2026
★★★★★ 5
the best shelves
Size: 4 pcs: 15.7*5.7, Color: Black, Size: 4 pcs: 15.7*5.7, Color: Black
bought these after another set of floating shelves didn't work. these are great and an awesome value!! i've used these in my guest bathroom and also throughout my house. they look great everywhere and are much easier to hang compared to others. my husband was hesitant after the last shelves but these turned out amazing. they are very sturdy and hold a good amount of weight. i would recommend buying these compared to any others.
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Reviewed in the United States on May 24, 2026
★★★★★ 5
Easy intall
Easy install nice quality
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Reviewed in the United States on April 15, 2026
★★★★★ 5
Great Wall Shelves – Sturdy, Easy to Install, and a Fantastic Value!
Size: 4 pcs: 15.7*5.7, Color: White
I’m really happy with these wall shelves! They’re sturdy, well-built, and hold up perfectly under weight—no concerns about them sagging or bending. The installation was super simple, and everything was clearly labeled with no missing parts, which made the whole process smooth and stress-free.
I love that they come in a set of four, making them perfect for displaying books, plants, or decorative items in multiple spots around the room. The design is sleek and minimal, so they fit in with pretty much any style of decor.
Overall, these shelves are a great value, and I would definitely purchase them again. Highly recommend if you’re looking for reliable and easy-to-install shelving!
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Reviewed in the United States on November 7, 2024
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