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Description
APC Mouse Anti-Human CD42b Antibody (S-935-7)Product Specification Host Mouse Antigen CD42b Synonyms Platelet glycoprotein Ib alpha chain; GP Ib alpha; GPIb alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b alpha; GP1BA Accession P07359 Clone Number S 935 7 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood platelets Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD42b |
| Synonyms | Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA |
| Accession | P07359 |
| Clone Number | S-935-7 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood platelets |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD42b, also known as glycoprotein Ib alpha (GPIbα), is a type I transmembrane glycoprotein expressed on platelets and megakaryocytes. It is a key component of the GPIb-IX-V receptor complex, which plays a critical role in platelet adhesion and thrombus formation by binding to von Willebrand factor (vWF) at sites of vascular injury. CD42b interacts with various molecules, including thrombin, coagulation factors XI and XII, and P-selectin, contributing to hemostasis and thrombosis. Mutations or polymorphisms in CD42b are associated with diseases such as Bernard-Soulier syndrome and platelet-type von Willebrand disease.
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