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Description
CD5 Mouse mAb (S-576-35)Product Specification Host Mouse Antigen CD5 Synonyms T cell surface glycoprotein CD5, Lymphocyte antigen T1 Leu 1, LEU1 Immunogen Recombinant Protein Location Cell membrane Accession P06127 Clone Number S 576 35 Antibody Type Mouse mAb Isotype IgG1,k Application ICC, FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD5 |
| Synonyms | T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, LEU1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P06127 |
| Clone Number | S-576-35 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICC, FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | null |
| ICC | 1:100 | null |
Background
CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface of other cells.
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