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Description
eEF2 Recombinant Rabbit mAb (S-1976-35)Product Specification Host Rabbit Antigen eEF2 Synonyms Elongation factor 2; EF 2; EF2; EEF2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P13639 Clone Number S 1976 35 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, A431, HEK 293, NIH 3T3, C6, human breast cancer, human cervix cancer, human stomach cancer, human colon, human liver Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | eEF2 |
| Synonyms | Elongation factor 2; EF-2; EF2; EEF2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P13639 |
| Clone Number | S-1976-35 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, A431, HEK-293, NIH/3T3, C6, human breast cancer, human cervix cancer, human stomach cancer, human colon, human liver |
| Predicted Reactivity | Zf, Ck, Bv, Mrst, Hm |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| ICFCM | 1:500 | Hu |
Background
Eukaryotic elongation factor 2 (eEF2) is a crucial regulator of protein synthesis, belonging to the highly conserved guanosine triphosphatase (GTPase) family. It is essential for the elongation phase of protein translation, facilitating the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. eEF2's activity is tightly regulated by phosphorylation at Thr56 by eEF2 kinase (eEF2K), which inhibits its function and thus suppresses protein synthesis. This protein is ubiquitously expressed in various tissues and plays a significant role in normal cellular functions. However, its dysregulation is implicated in several diseases, including cancer, where overexpression of eEF2 is associated with increased tumor incidence and poorer patient prognosis.
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