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Description
Biotin Mouse Anti-Mouse NK1.1 Antibody (S-R480)Product Specification Host Mouse Antigen NK1. 1 Synonyms Killer cell lectin like receptor subfamily B member 1B allele A; CD161 antigen like family member B; Lymphocyte antigen 55b (Ly 55b); NKR P1 34; Natural killer cell surface protein NKR P1B allele SJL BALB (NKR P1B); CD161b; Ly55b; Nkrp1b; Klrb1b Location Membrane Accession P27812 Clone Number S R480 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6
Product Specification
| Host | Mouse |
| Antigen | NK1.1 |
| Synonyms | Killer cell lectin-like receptor subfamily B member 1B allele A; CD161 antigen-like family member B; Lymphocyte antigen 55b (Ly-55b); NKR-P1 34; Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B); CD161b; Ly55b; Nkrp1b; Klrb1b |
| Location | Membrane |
| Accession | P27812 |
| Clone Number | S-R480 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
NK1.1, also known as KLRB1C and NKRP1C, is a type II integral membrane glycoprotein with a C-type lectin domain and belongs to the NKR-P1 family of cell surface receptors. It is expressed as a disulfide-linked homodimer on all NK and NKT cells in some strains of mice, particularly serving as a good marker for these cell types in the C57BL/6 genetic background. NK1.1 associates with the ITAM-bearing γ-chain adaptor molecule and does not engage ligands with an MHC class-I-like fold, but interacts with C-type lectin-like CLEC2 glycoproteins. Although crosslinking of the NK1.1 receptor using a specific mAb can induce NK cell-mediated cytotoxicity and effector cytokine secretion, the in vivo functions of NK1.1 and the identity of its ligand(s) are still not fully understood.
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