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Description
MDR3 Recombinant Rabbit mAb (SDT-1949-60)Product Specification Host Rabbit Antigen MDR3 Synonyms Phosphatidylcholine translocator ABCB4; ATP binding cassette sub family B member 4; Multidrug resistance protein 3; P glycoprotein 3; MDR3; PGY3; ABCB4 Immunogen Synthetic Peptide Location Cell membrane, Cytoplasm Accession P21439 Clone Number SDT 1949 60 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu, Ms, Rt Positive Sample Human liver, mouse liver, rat liver
Product Specification
| Host | Rabbit |
| Antigen | MDR3 |
| Synonyms | Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; MDR3; PGY3; ABCB4 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cytoplasm |
| Accession | P21439 |
| Clone Number | SDT-1949-60 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human liver, mouse liver, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500-1:1000 | Hu, Ms, Rt |
Background
Multidrug Resistance Protein 3 (MDR3), also known as ATP-binding cassette sub-family B member 4 (ABCB4), is a crucial protein primarily expressed in the canalicular membrane of hepatocytes. It functions as a phosphatidylcholine translocase, transporting this phospholipid from the inner to the outer leaflet of the membrane bilayer and into bile. This process is essential for forming mixed micelles with bile salts, protecting the biliary tree from the detergent-like toxicity of bile salts. MDR3 plays a significant role in bile formation and preventing cholestasis. Mutations in the ABCB4 gene can lead to severe liver disorders, such as Progressive Familial Intrahepatic Cholestasis type 3 (PFIC3), characterized by early-onset cholestasis, liver fibrosis, and eventual liver failure. Additionally, MDR3 dysfunction has been linked to drug-induced liver injury (DILI) due to its inhibition by certain drugs or their metabolites.
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