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For Your Every Summer RSVP, with Code: SUMMER15
Description
GDF15 Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms GDF 15; MIC 1; NAG 1; PDF; PLAB; PTGFB; GDF15; MIC1; RG 1; Placental TGF beta; PTGF beta; PTGFBPTGF beta; Placental TGF ; PTGF ; PTGFBPTGF Accession G7PWZ3 Amino Acid Sequence Arg193 Val308 with N Terminus His tag Expression System E. coli Molecular Weight 15 18 kDa Purity >95% by Bis Tris PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer
Product Specification
| Species | Cynomolgus |
| Synonyms | GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β |
| Accession | G7PWZ3 |
| Amino Acid Sequence |
Arg193-Val308 with N-Terminus His tag |
| Expression System | E.coli |
| Molecular Weight |
15-18 kDa
|
| Purity | >95% by Bis-Tris PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM HAc (pH 2.9), 8% trehalose |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9).
|
| Stability & Storage |
-20 to -80°C for 12 months as supplied from date of receipt. |
Background
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
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