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Description
Alexa Fluor® 488 Mouse Anti-Human CD154 Antibody (S-R579)Product Specification Host Mouse Antigen CD154 Synonyms CD40 ligand; CD40 L; T cell antigen Gp39; TNF related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG Location Secreted, Cell membrane Accession P29965 Clone Number S R579 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample PMA and Ionomycin treated human PBMC Purification Protein G Concentration 0. 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD154 |
| Synonyms | CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG |
| Location | Secreted, Cell membrane |
| Accession | P29965 |
| Clone Number | S-R579 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | PMA and Ionomycin treated human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD154, also known as CD40 ligand (CD40L) or gp39, is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated CD4+ T cells and can also be found on other immune cells such as CD8+ T cells, natural killer cells, platelets, dendritic cells, and endothelial cells. CD154 can form a trimeric structure and is crucial for humoral and cellular immunity. Its interaction with CD40, its classical receptor, is essential for B cell activation, proliferation, isotype switching, and germinal center formation. This interaction also plays a significant role in T cell priming and cell-mediated immune responses. In addition to CD40, CD154 can bind to several integrins, including αIIbβ3, α5β1, and αMβ2, which are involved in various inflammatory and immune processes. Abnormal expression of CD154 has been implicated in several autoimmune diseases, such as systemic lupus erythematosus (SLE), where it contributes to the overproduction of autoantibodies and inflammation.
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