SKU: 51738867811

Biotinylated SIRP-α/CD172A Fc&Avi Tag Protein, Mouse

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Description

Biotinylated SIRP-α/CD172A Fc&Avi Tag Protein, MouseProduct Specification Species Mouse Synonyms BIT, MFR, MYD1, P84, PTPNS1,SHP substrate 1, SHPS1, SHPS1, CD172A Accession P97797 1 Amino Acid Sequence Lys32 Asn373, with C hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 95 110kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Mouse
Synonyms BIT, MFR, MYD1, P84, PTPNS1,SHP substrate 1, SHPS1, SHPS1, CD172A
Accession P97797-1
Amino Acid Sequence Lys32-Asn373, with C-hIgG1 Fc and Avitag
Expression System HEK293
Molecular Weight 95-110kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Barclay, A.N. & M.H. Brown (2006) Nat. Rev. Immunol. 6:457. 2. vanBeek, E.M. et al. (2005) J. Immunol. 175:7781. 3. Liu, Y. et al. (2005) J. Biol. Chem. 280:36132. 4. Kharitonenkov, A. et al. (1997) Nature 386:181.

Background

Signal regulatory protein alpha (SIRP alpha, designated CD172a), also called SHPS-1 (SHP substrate 1) and previously, MyD-1 (Myeloid/Dendritic-1), is a monomeric ~90 kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPs are paired receptors, with similar extracellular domains but differing C-termini and functions. The 503 amino acid (aa) human SIRP alpha contains a 342 aa extracellular domain (ECD), with one V-type, and two C1 type Ig domains, and three potential N glycosylation sites. It has a 110 aa cytoplasmic sequence with ITIM motifs that recruit tyrosine phosphatases SHP-1 and SHP-2 when phosphorylated.SIRP alpha is expressed mainly on myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It is also found on neurons, smooth muscle and endothelial cells. SIRP alpha shows adhesion to the ubiquitous CD47/IAP (integrin associated protein), while SIRP gamma binds more weakly and SIRP alpha 1 does not bind at all.Mouse and human SIRP alpha -CD47 binding only cross-reacts for specific polymorphisms and influences engraftment of xenotransplanted stem cells. SIRP alpha engagement generally produces a negative regulatory signal. Low SIRP alpha recognition of CD47, which occurs on aged erythrocytes or platelets or xenogenic cells, promotes clearance of CD47low cells from circulation. SIRP alpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.

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SKU: 51738867811

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Terese E Wood
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★★★★★ 5
Easy for kids to use
Size: 5 Ounce (Pack of 2)
My son uses this when he's outside because constantly gets bites. He's 7 and can spray it himself and no bites when he uses it. Would highly recommend. Does linger in the air after so I don't recommend using in the garage
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Reviewed in the United States on December 15, 2025
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Tania
Lowell, US
★★★★★ 5
Agradecida por el producto por mis nietos
Size: 5 Ounce (Pack of 2)
Magnífico
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Reviewed in the United States on May 25, 2026
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T-Dawg
Fort Morgan, US
★★★★★ 5
Works well to prevent sunburn and stays on while working.
Size: 6 Ounce (Pack of 1), Style: Spray
This sunscreen is great! I've worked outside in New Mexico sun for the past few years and this is a life saver. Goes on evenly and doesn't come off while I'm working in the heat.
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Reviewed in the United States on March 25, 2026
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Bridhid Farrelly
Cuba, US
★★★★★ 5
Sunscreen 100 proof
Size: 6 Ounce (Pack of 1), Style: Spray
Works great
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Reviewed in the United States on May 16, 2026
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MazeMama
Cuba, US
★★★★★ 5
Fabulous, especially for sensitive skin and those with aversion to textures.
Size: 6 Ounce (Pack of 1), Style: Spray
Keeps my skin from turning UGLIER. THIS actually WORKS. I do not wish to be any tanner than I come naturally, and this is the BEST sunscreen I've ever used. I do use a wipe to remove the overspray from my eye area. It does not irritate my incredibly sensitive skin, and sprays on easily..like a dream. No more sandy spf moments!..I can't stand that creamy+oily stuff all over my hands then throw in a little sand - now we have a sensory concern..NOT WITH THIS STUFF!! Highly recommend. Easy to use. KeyWest rays had nothing on this..we came back slightly tan, not burnt, and not a looking like a different ethicity. Reapply as recommend.
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Reviewed in the United States on September 26, 2025

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