Pay in installments of $60.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 14 - Aug 19
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Her4 His Tag Protein, HumanProduct Specification Species Human Synonyms Her4, ERBB4, 4ICD, MGC138404, p180erbB4 Accession Q15303 Amino Acid Sequence Gln26 Pro651, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | Her4, ERBB4, 4ICD, MGC138404, p180erbB4 |
| Accession | Q15303 |
| Amino Acid Sequence | Gln26-Pro651, with C-terminal 10*His QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 87-101kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352. 2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898. |
Background
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.9 ★★★★★
Based on 14 reviews
Sort
Product Reviews
★★★★★ 3
The book itself is good. The content may be awkward or detailed in ...
Format: Paperback
The book itself is good. The content may be awkward or detailed in a way that makes reading tedious and a bit less enjoyable than what likw.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2016
★★★★★ 5
Nursing school book that helps
Format: Paperback
I use this book for nursing school :0.
The book covers a broad range of topics including cardiovascular diseases, respiratory conditions, diabetes, mental health, and much more. Each chapter is written by experts in the field, providing a high level of expertise and insight into best practices for managing various medical conditions.
One of the things I appreciate about this book is the clear and concise writing style. The guidelines are presented in a format that is easy to understand and follow, making it an ideal resource for busy practitioners. Additionally, the authors have included helpful algorithms and decision trees to aid in the management of complex cases.
Another strength of this book is the emphasis on evidence-based medicine. The guidelines are based on the latest research and are regularly updated to reflect new developments in the field. This ensures that healthcare professionals can provide the most effective and appropriate care for their patients.
Overall, I highly recommend Clinical Guidelines in Primary Care for healthcare professionals working in primary care settings. It is a comprehensive and practical guide that provides evidence-based recommendations for the diagnosis and management of a wide range of medical conditions.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 19, 2023
★★★★★ 5
Great Resource
Format: Paperback
As a resource for NP school (and even after, I'm sure), this book is fantastic. I recommend it to anyone asking if it's worth it. I, however, refer them to a different site than Amazon as it is cheaper straight from the publisher. Significantly so. A hundred dollars difference doesn't quite justify the next day or 2-day delivery.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 2, 2025
★★★★★ 5
So good for soap notes!
Format: Paperback
I wish I could have gotten this sooner when we had to write soap notes. It explains the illness, symptoms, tests, treatments, referrals and follow ups. I got it used and it came in great condition. Would definitely buy again!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 12, 2024
★★★★★ 5
Bible!
Format: Paperback
This book has been my life line with school. Freaking amazing and worth every penny.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 22, 2024