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Description
Nucleophosmin/NPM Recombinant Rabbit mAb (S-R231)Product Specification Host Rabbit Antigen Nucleophosmin NPM Synonyms Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1 Location Nucleus, Nucleolus Accession P06748 Clone Number S R231 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | Nucleophosmin/NPM |
| Synonyms | Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1 |
| Location | Nucleus, Nucleolus |
| Accession | P06748 |
| Clone Number | S-R231 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:250 | null |
| ICFCM | 1:500 | null |
| IP | 1:50 | null |
| ICC | 1:500 | null |
Background
Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the protein's regulation and cellular functions. It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. The protein is phosphorylated.
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