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Description
Alexa Fluor® 647 Mouse Anti-Rat CD25 Antibody (S-R676)Product Specification Host Mouse Antigen CD25 Synonyms Peripheral myelin protein 22; PMP 22; Protein CD25; SR13 myelin protein; Schwann cell membrane glycoprotein (SAG); Pmp22 Location Cell membrane Accession P25094 Clone Number S R676 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes treated 4h with 10g ml LPS Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical
Product Specification
| Host | Mouse |
| Antigen | CD25 |
| Synonyms | Peripheral myelin protein 22; PMP-22; Protein CD25; SR13 myelin protein; Schwann cell membrane glycoprotein (SAG); Pmp22 |
| Location | Cell membrane |
| Accession | P25094 |
| Clone Number | S-R676 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes treated 4h with 10μg/ml LPS |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Rt |
Background
CD25, also known as the interleukin-2 receptor alpha chain (IL-2Rα), is a membranous glycoprotein that forms the alpha chain of the IL-2 receptor complex. It is primarily expressed on activated T lymphocytes and plays a crucial role in regulating immune responses by mediating IL-2 signaling. When combined with IL-2Rβ and the common γ chain, CD25 forms a high-affinity receptor complex that enhances the binding and signaling of IL-2, promoting T-cell proliferation and activation. Additionally, CD25 is involved in the development and function of regulatory T cells, which help maintain immune tolerance and prevent autoimmune diseases. Abnormal expression of CD25 has been associated with various diseases, including autoimmune disorders and certain cancers, making it a potential target for therapeutic interventions.
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