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Description
Alexa Fluor® 647 Rat Anti-Mouse TCR Vα2 Antibody (S-R698)Product Specification Host Rat Antigen TCR V2 Synonyms T cell receptor alpha chain constant; Trac Location Cell membrane Accession P01849 Clone Number S R698 Antibody Type Rat mAb Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 02mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date
Product Specification
| Host | Rat |
| Antigen | TCR Vα2 |
| Synonyms | T-cell receptor alpha chain constant; Trac |
| Location | Cell membrane |
| Accession | P01849 |
| Clone Number | S-R698 |
| Antibody Type | Rat mAb |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.02mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
The TCR Vα2 protein (T Cell Receptor Vα2) is a variable region (V region) subtype of the T cell receptor (TCR) α chain and belongs to the immunoglobulin superfamily. TCR is a key molecule on the surface of T cells that specifically recognizes antigens, composed of an α chain and a β chain (or γ chain and δ chain), with Vα2 being a specific type of variable region in the α chain. The Vα2 region directly participates in antigen recognition by binding to antigen peptides presented by major histocompatibility complex (MHC) molecules, initiating T cell immune responses. The diversity of TCR Vα2 is generated through V-J gene rearrangement, a mechanism that enables T cells to recognize a wide range of antigens, thereby contributing to the diversity of adaptive immunity. TCR Vα2 plays a significant role in autoimmune diseases, infectious immunity, and tumor immunity, and its abnormal expression or function may be associated with immune dysregulation. Studying TCR Vα2 helps to elucidate the mechanisms of T cell-mediated immune responses and provides a theoretical foundation for developing T cell-based immunotherapies.
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