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Description
Phospho-Rb (Ser807/811) Recombinant Rabbit mAb (S-2215-52)Product Specification Host Rabbit Antigen Phospho Rb (Ser807 811) Synonyms Retinoblastoma associated protein; p105 Rb; p110 RB1; pRb (Rb); pp110; RB1 Immunogen Synthetic Peptide Location Nucleus Accession P06400 Clone Number S 2215 52 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample WI 38, C2C12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Rb (Ser807/811) |
| Synonyms | Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb (Rb); pp110; RB1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P06400 |
| Clone Number | S-2215-52 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | WI-38, C2C12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Phospho-Rb (Ser807/811) protein refers to the phosphorylated form of the retinoblastoma protein (Rb) at serine residues 807 and 811. The retinoblastoma protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, particularly in controlling the transition from the G1 to S phase. When phosphorylated at Ser807/811, Rb undergoes a conformational change that allows it to release the transcription factor E2F, which in turn promotes cell cycle progression. This phosphorylation is mainly mediated by cyclin-dependent kinases (CDKs) such as CDK4 and CDK6, and it is tightly regulated to ensure proper cell cycle control. Abnormal phosphorylation of Rb at these sites is often associated with various cancers, highlighting its significance in maintaining genomic stability and preventing uncontrolled cell proliferation.
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