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Description
Biotinylated LILRB2/CD85d/ILT4 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LIR2, MIR10, ILT 4 Accession Q8N423 Amino Acid Sequence Gly24 His458 with Human IgG1 Fc & Avi Tag at the C terminus Expression System HEK293 Molecular Weight 80 95 kDa(Reducing) Purity >95% by SDS PAGE; 90% by SEC HPLC Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS PH7. 4 5% trehalose Stability & Storage 12 months from date of
Product Specification
| Species | Human |
| Synonyms | LIR2, MIR10, ILT-4 |
| Accession | Q8N423 |
| Amino Acid Sequence | Gly24-His458 with Human IgG1 Fc & Avi Tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-95 kDa(Reducing) |
| Purity | >95% by SDS-PAGE;90% by SEC-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Bai R, Guo J. SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling. Biol Direct. 2025 Jun 23;20(1):73. |
Background
ILT4 (LILRB2) is an inhibitory receptor of the LIR-B subfamily, featuring two or four extracellular Ig domains, a transmembrane segment, and two to four cytoplasmic ITIMs. It binds class I MHC molecules (HLA-A, -B, -C, -G) and competes with CD8A for these ligands. LILRB2 dampens FCGR1A-mediated phosphorylation and Ca²⁺ mobilization, thereby restraining inflammatory responses and cytotoxicity to limit autoreactivity and focus immune responses.
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