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Description
Desmocollin-2/3(DSC2/3) Recombinant Rabbit mAb, PBS Only (SDT-2102-59)Product Specification Host Rabbit Antigen Desmocollin 2 3(DSC2 3) Synonyms Cadherin family member 2; Desmosomal glycoprotein II; Desmosomal glycoprotein III; CDHF2 Immunogen Recombinant Protein Location Cell membrane Accession Q02487 Clone Number SDT 2102 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, A431, PC 3, HepG2, human tonsil, human cardiac muscle, human prostate, human esophagus, human
Product Specification
| Host | Rabbit |
| Antigen | Desmocollin-2/3(DSC2/3) |
| Synonyms | Cadherin family member 2; Desmosomal glycoprotein II; Desmosomal glycoprotein III; CDHF2 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q02487 |
| Clone Number | SDT-2102-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, A431, PC-3, HepG2, human tonsil, human cardiac muscle, human prostate, human esophagus, human oral squamous cell carcinoma, human head and neck squamous cell carcinoma |
| Predicted Reactivity | / |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
Background
Desmocollin-2/3 (DSC2/3) are transmembrane proteins belonging to the calcium-dependent cadherin superfamily and are essential components of desmosomes, which are intercellular junctions that provide structural integrity to epithelial tissues. These proteins mediate cell-cell adhesion through homophilic and heterophilic interactions with other desmosomal cadherins, such as desmogleins. DSC2/3 play crucial roles in maintaining tissue cohesion, especially in mechanically stressed environments. Abnormal expression or dysfunction of DSC2/3 has been implicated in various diseases, including skin blistering disorders like pemphigus and arrhythmogenic cardiomyopathy. In cancer, DSC2/3 can have dual roles, acting as tumor suppressors or promoters depending on the context. For example, DSC2 is downregulated in many cancers, such as hepatocellular carcinoma and gastric cancer, where it inhibits cell proliferation and promotes apoptosis. Conversely, in some cancers like pancreatic cancer, loss of DSC2/3 may lead to increased cell migration and metastasis.
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