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Description
B7-2/CD86 His Tag Protein, HumanProduct Specification Species Human Accession P42081 Amino Acid Sequence Leu26 Pro247, with C terminal 8*His LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPHHHHHHHH Expression System HEK293 Molecular Weight 40 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Human |
| Accession | P42081 |
| Amino Acid Sequence | Leu26-Pro247, with C-terminal 8*His LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 40-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
CD86 encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
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4.1 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
An in depth American perspective on the Depression to World War
Format: Kindle
In depth, scholarly book from an American perspective of World War II. The discussion of the home perspective on the war was enlightening. An excellent read. Comprehensive look at the American political world from depression to World War.
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Reviewed in the United States on February 2, 2016
★★★★★ 5
He explains how the Rosie the riveter myth is pretty much a fabrication and how America's approach to manufacturing ...
Format: Kindle
Trying to distill WWll down to a little over 400 pages is a Herculean task but Mr. Kennedy does a serviceable job. He provides thumbnail sketches of the major players' personalities and tics. He does an admirable job of jumping back and forth between the European and Pacific theaters of operation, always keeping in mind America's POV in explaining how FDR and his staff dealt with their fractious, troublesome allies. He explains how the Rosie the riveter myth is pretty much a fabrication and how America's approach to manufacturing was able to out produce the German mode of war production: America going for Quantity vs. the German fixation with Quality. Lots interesting information and facts. There are areas where I thought he could have used more depth such as the death of FDR (probably no more than two pages.if that); Mussolini and Hitler's last hours are given mere paragraphs; Churchill being voted out of office just months shy of victory in Europe is given maybe two paragraphs and while he mentions how Tibetts went to the airplane factory to pick the future Enola Gay off the assembly line he gives short shrift the immensely expensive and technically complex challenge of building the A-bomb. Nor does Mr. Kennedy mention that when HST hinted to Stalin that America had an powerful new weapon Stalin was all ready aware of the activities going on at Trinity and of the Manhattan Project. Mr. Kennedy doesn't offer any new information or insights but this is a good, one-book overview, of the war.
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Reviewed in the United States on October 3, 2014
★★★★★ 4
Thorough But Easily Read Historical Account
Format: Paperback
I bought this book thinking it would be an account of civilian life in the U.S. during WWII. But I was surprised to see that it focused almost exclusively on the military campaigns and the decisions behind them. There was sporadic mention of life on the homefront, but mostly the book is a book about the war. Which is not a criticism. Kennedy deftly and thoroughly takes us through the war, outlines for us the challenges and opportunities and how the leaders of the affected nations developed their strategies. In addtion to the fine details of history, Kennedy writes in such a fashion that this book will probably appeal to the scholar and the layman with equal strength. As someone long in the tooth, I knew most of the history of WWII, but if you are younger and want a comprehensive, well-written history an epic period in world history, you could do a lot worse than read this compelling book.
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Reviewed in the United States on November 17, 2010
★★★★★ 5
Thought provoking
Format: Kindle
A insightful look at the American people and the world leaders of the second world war it's beginnings and after effects.
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Reviewed in the United States on January 2, 2025
★★★★★ 5
Excellent! Finally finished both Freedom from Fear Histories and, I feel that I should personally thank him. These were the tw
Format: Kindle
Excellent ! Thanks to David Kennedy for writing Freedom from Fear! The best 20th Century history ever. Now I must allocate the time to read again!!!
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Reviewed in the United States on January 26, 2016