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Description
PE Mouse Anti-Human CD42b Antibody (S-935-7)Product Specification Host Mouse Antigen CD42b Synonyms Platelet glycoprotein Ib alpha chain; GP Ib alpha; GPIb alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b alpha; GP1BA Immunogen Recombinant Protein Location Membrane Accession P07359 Clone Number S 935 7 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 05mg ml Conjugation PE Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | CD42b |
| Synonyms | Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P07359 |
| Clone Number | S-935-7 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD42b, also known as platelet glycoprotein Ib alpha chain (GPIbα), is a type I transmembrane glycoprotein with a molecular weight of approximately 145 kDa. It is encoded by the GP1BA gene and primarily expressed on the surface of platelets and megakaryocytes. CD42b forms a complex with other proteins, including CD42c (GPIbβ), CD42a (GPIX), and CD42d (GPV), which is essential for platelet adhesion and aggregation. This complex plays a crucial role in hemostasis by binding to von Willebrand factor (vWF), facilitating platelet attachment to the subendothelium at sites of vascular injury. Mutations or deficiencies in CD42b are associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by large platelets and impaired platelet function.
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