SKU: 38087471941

UBE3A His&Flag Tag Protein, Human

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Description

UBE3A His&Flag Tag Protein, HumanProduct Specification Species Human Synonyms CTCL tumor antigen se37 2, Human papilloma virus E6 associated protein, Oncogenic protein associated protein E6 AP Accession Q05086 2 Amino Acid Sequence Lys2 Leu852, with N terminal10*His Flag

Product Specification


Species Human
Synonyms CTCL tumor antigen se37-2, Human papilloma virus E6-associated protein, Oncogenic protein-associated protein E6-AP
Accession Q05086-2
Amino Acid Sequence

Lys2-Leu852, with N-terminal10*His-Flag HHHHHHHHHHDYKDDDDKKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM
Expression System Baculovirus-InsectCells
Molecular Weight 95kDa
Purity >90% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag, Flag Tag
Physical Appearance Liquid
Storage Buffer 20mM Tris, 500mM NaCl, 10% Glycerol, 1mM EDTA, 3mM DTT, pH8.0
Reconstitution N.A
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Reference

1.J Biol Chem. 2009 Apr 17;284(16):10537-45.
2.Nucleic Acids Res. 2014 May;42(9):5765-75.Epub 2014 Apr 11.
3.J Biol Chem. 2009 Apr 17;284(16):10537-45. Epub 2009 Feb 20.
4. Mol Endocrinol. 2006 Oct;20(10):2343-54.Epub 2006 Jun 13.

Background

E3 ubiquitin-protein ligase (UBE3A) which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. It Plays an important role in the regulation of the circadian clock, leading to its proteasomal degradation. UBE3A acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation and as a regulator of synaptic development by mediating ubiquitination and degradation of ARC.

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SKU: 38087471941

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4.8 ★★★★★
Based on 17 reviews
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T
Verified Purchase
T. Beard
Whiting, US
★★★★★ 5
Very Nice Tire Kit
Size: 36 pcs
Put together very well. Nice little kit - all packed up perfectly for easy storage in your vehicle. Quality zipper pouch and the tools look great in it. I have not fixed a flat tire with it but it is handily placed in my vehicle for such an occasion. Glad I bought it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 1, 2026
M
Verified Purchase
Ms R
Dallas, US
★★★★★ 5
Great for many ways on my leather goods!
Size: 16 Fl Oz (Pack of 1)
This stuff got the smell out of a purse I bought that had a chemical smell online. I mean, I try to wash this person all kinds of stuff and couldn't get the stink out of it. I thought I was gonna have to throw it out. I bought this at the last attempt to fix it and it got rid of the smell! I also used it on all my leather shoes, and I cleaned my leather headboard. All shiny and moist now. I know this is for cars, but I don't have any leather seats in my cars. But everything I used it on is clean and smells better.
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Reviewed in the United States on May 2, 2026
A
Verified Purchase
Amazon Customer
Natrona Heights, US
★★★★★ 5
Keeping it clean!
Size: 32 Fl Oz (Pack of 1)
Great product.
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Reviewed in the United States on May 19, 2026
A
Verified Purchase
Amazon Customer
Louisville, US
★★★★★ 5
The smell is wonderful
Size: 16 Fl Oz (Pack of 1)
This product smells really nice. Like clean fresh leather. My seats look nice. My dog had an accident all over the front of my seat and after cleaning thoroughly, this seemed to really help.
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Reviewed in the United States on May 21, 2026
B
Verified Purchase
Benjamin
Belleville, US
★★★★★ 4
Chemical Guys Leather Quick Detailer for Car Interiors 32oz
Size: 32 Fl Oz (Pack of 1)
Reliable Quick Cleaner for Leather Interiors I’ve been using the Chemical Guys Leather Quick Detailer on my car’s interior for a while now, and it’s become one of those go-to products I like to keep on hand. As the name suggests, this is designed for quick touch-ups rather than deep cleaning, and for that purpose, it really does the job well. The first thing I noticed is how easy it is to use. A couple of sprays on the leather seats or steering wheel, a quick wipe with a microfiber cloth, and the surface instantly looks cleaner. It removes light dust, dirt, and fingerprints in seconds. Unlike some products I’ve tried in the past, it doesn’t leave behind a slick or greasy feel, which is important when you’re dealing with things like a steering wheel or gear shifter that you’re constantly touching. Instead, the finish is clean, soft, and natural-looking, which is exactly what I want. The scent is another plus. It has a pleasant, subtle leather fragrance that makes the car smell fresh without being overwhelming or chemical-like. I don’t like products that leave behind a strong odor, and this one strikes the right balance. Another strength is its versatility. While it’s marketed as a car interior detailer, I’ve found it works well on other small leather items, like a laptop bag or even a chair at home. Obviously, it’s not a replacement for a full leather conditioner, but for light upkeep it’s nice to have a single product that can handle more than just my car. That said, there are a few things that keep this from being a perfect 5-star product. First, it’s definitely not designed for deep cleaning—if your leather is heavily soiled, stained, or dried out, this won’t be enough. You’d need a dedicated cleaner and conditioner for a full restoration. Second, the spray nozzle can be a bit inconsistent, sometimes giving off more of a stream than a fine mist. It’s not a huge issue, but it can waste product or make application less even if you’re not careful. Lastly, while it makes leather look clean and refreshed, it doesn’t provide as much conditioning as some other products, so if you’re looking for something that really nourishes and protects long term, this is more of a maintenance step than a solution. Overall, though, I’m very satisfied. The Chemical Guys Leather Quick Detailer is perfect for keeping leather looking sharp between major cleanings. It’s fast, effective, and leaves behind a clean finish without unwanted residue. It saves me time and keeps my car interior looking well cared for, which is exactly what I want from a quick detailer. I’d rate it 4 stars—an excellent product for regular maintenance and touch-ups, with just a few small shortcomings that prevent it from being the ultimate all-in-one leather care solution.
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Reviewed in the United States on September 9, 2025

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