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Description
PML Recombinant Rabbit mAb (S-1908-60)Product Specification Host Rabbit Antigen PML Synonyms Protein PML; E3 SUMO protein ligase PML; Promyelocytic leukemia protein; RING finger protein 71; RING type E3 SUMO transferase PML; Tripartite motif containing protein 19 (TRIM19); MYL; PP8675; RNF71; TRIM19 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Endosome, Endoplasmic reticulum Accession P29590 Clone Number S 1908 60 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC
Product Specification
| Host | Rabbit |
| Antigen | PML |
| Synonyms | Protein PML; E3 SUMO-protein ligase PML; Promyelocytic leukemia protein; RING finger protein 71; RING-type E3 SUMO transferase PML; Tripartite motif-containing protein 19 (TRIM19); MYL; PP8675; RNF71; TRIM19 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Endosome, Endoplasmic reticulum |
| Accession | P29590 |
| Clone Number | S-1908-60 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HUVEC, 293T, HeLa, K562, human breast cancer, human lung squamous carcinoma, human prostate cancer, human testis |
| Predicted Reactivity | / |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
Promyelocytic leukemia protein (PML), also known as TRIM19, is a multifunctional protein belonging to the TRIM family and is best known for its role in the formation and stability of PML nuclear bodies (PML-NBs) within the cell nucleus. These nuclear bodies are membraneless organelles that serve as hubs for various cellular processes, including transcriptional regulation, DNA damage repair, apoptosis, and antiviral defense. PML itself is a 70 kDa protein with an N-terminal RBCC motif (RING, B-box, and coiled-coil domains) that facilitates its oligomerization and interaction with over 160 other proteins. The protein is also subject to post-translational modifications such as SUMOylation, phosphorylation, and ubiquitination, which regulate its function and localization. PML has been implicated as a tumor suppressor, with its downregulation observed in various cancers, highlighting its importance in maintaining cellular homeostasis and preventing carcinogenesis.
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