SKU: 35391134062

S-RMab® Nectin-4 Recombinant Rabbit mAb,PBS Only (SDT-277-314)

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Description

S-RMab® Nectin-4 Recombinant Rabbit mAb,PBS Only (SDT-277-314)Product Specification Host Rabbit Antigen Nectin 4 Synonyms LNIR, PRR4, PVRL4 Immunogen Recombinant Protein Location Cell membrane Accession Q96NY8 Clone Number SDT 277 314 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution, 4 C as supplied

Product Specification


Host Rabbit
Antigen Nectin-4
Synonyms LNIR, PRR4, PVRL4
Immunogen Recombinant Protein
Location Cell membrane
Accession Q96NY8
Clone Number SDT-277-314
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS
Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000
IHC-P 1:500

Background

Nectin-4 (Nectin cell adhesion molecule 4) is a type I transmembrane cell adhesion molecule belonging to the Nectin family. A homolog formerly known as the poliovirus receptor (PVR/CD155) is also known as the poliovirus receptor associated (PRR) protein. During physiological development, Nectin-4 is specifically expressed during embryonic and fetal development and is very low expressed in adult tissues. It forms physical connections between neighboring cells and is essential for enabling intercellular communication, migration, and other important cellular processes. Nectin-4 is overexpressed in a variety of tumor cells, and Nectin-4 is used as a marker for cancer recurrence and metastasis, which is associated with poor prognosis of a variety of cancers, including uroepithelial carcinoma, breast cancer, ovarian cancer, pancreatic cancer, non-small cell lung cancer, gastric cancer, hepatocellular carcinoma and bladder cancer. Nectin-4 can promote tumor cell proliferation and differentiation, angiogenesis, lymphangiogenesis and lymphatic metastasis through activation of PI3K/AKT pathway, playing an important role in the occurrence and metastasis of cancer. Nectin-4 is also an independent biomarker associated with poor overall survival in some cancer types. Due to its high specific expression in tumors, drug studies targeting this target have emerged.

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SKU: 35391134062

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4.4 ★★★★★
Based on 15 reviews
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Product Reviews
H
Helly
Natrona Heights, US
★★★★★ 5
Revives my idealistic heart to hold out for real peace
Format: Paperback
Sometimes it's easy to think the world has become so murky that truth barely matters any more. Kazu Haga keeps it real and shows us how to be nonviolent without becoming martyrs to the cause. The book acts as a reminder that taking a principled stand on violence is the only way change has occurred in history, but also acknowledges that we need to love our whole selves and use our brains to step outside habitual patterns of trauma-triggered violence.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 20, 2020
D
Verified Purchase
David
Bozeman, US
★★★★★ 5
Good for general knowledge!
Format: Paperback
I'm an IT guy but not an Active Directory SME. If it doesn't have a command line and doesn't route or switch I quickly fall off the cliff of interest in it. That being said, I needed to have a good starting guide and future reference guide to Active Directory so after some Google'ing I settled on this book. While I haven't read it cover to cover yet, I have used it to study up on a few specific areas of AD. It's also got a permanent spot near by work desk for use as a reference guide as needed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 7, 2024
L
Verified Purchase
Looks great!
Lowell, US
★★★★★ 5
Good info that helps
Format: Paperback
This had info that helped our AD lockouts issues or at least ease the pain while our vendor figures it out. A powershell command that unlocks all AD users instead of having to unlock each one. In the troubleshooting section
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 30, 2024
G
Greg D.
Chelsea, US
★★★★★ 5
More than just the most comprehensive book on AD
Format: Paperback
I have been working with Active Directory since it was released in 2000 and even before that if you count its predecessor Exchange's directory. I can confidently say that this is the most comprehensive book on Active Directory that I have ever read. Of course there are all of the basics like designing AD structures, migrations to AD 2022, management of objects and group policies but then all of the AD services are also covered in-depth like DNS, DS, LDS, FS, RMS and CS. Furthermore this book tackles trusts, database maintenance and backup and recovery. While not a book about Azure AD, there is a ton of information about Azure AD. The author takes the time and effort to compare AD with Azure AD and there are hundreds of references to Azure AD in terms of building out hybrid AD environments, federated identity and notes about how things are done in Azure AD versus AD. The chapter on PowerShell demonstrates scripts for both AD and Azure AD. Here is what I think makes this book special though, and it is how the entire context for the book is around security, identity and access management. Essentially this book can be viewed as a book on security, identity and access management that demonstrates how to practically implement those concepts in Active Directory and Azure AD. There is fantastic information that explains the concepts of identity and access management clearly and concisely and covers topics such as zero trust, privileged access management (PAM) and more. Then, these concepts are translated into how they are implemented in Active Directory. It's a great way to present the information as it provides real world context and clearly explains the purpose of Active Directory versus purely just describing technical features and functionality. This is the way all technical books should be written.
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Reviewed in the United States on December 10, 2021
J
Verified Purchase
Joseph Hatch
Charlottesville, US
★★★★★ 4
Missing some ToC Pages
Format: Paperback
Item shipped missing the first couple pages from the Table of Contents. Otherwise, it is as expected. Using as AD Services reference in Enterprise IT office for junior admins to reference.
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Reviewed in the United States on February 21, 2026

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