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Description
FLT-3L Protein, HumanProduct Specification Species Human Synonyms Fms related tyrosine kinase 3 ligand,Flt3 ligand,Flt3L,SL cytokine, Accession P49771 Amino Acid Sequence Thr27 Pro185, with C terminal hFc Tag Expression System HEK293 Molecular Weight 55 65 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg
Product Specification
| Species | Human |
| Synonyms | Fms-related tyrosine kinase 3 ligand,Flt3 ligand,Flt3L,SL cytokine, |
| Accession | P49771 |
| Amino Acid Sequence | Thr27-Pro185, with C-terminal hFc Tag |
| Expression System | HEK293 |
| Molecular Weight | 55-65 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Blood. 2002 Sep 1;100(5):1532-42. |
Background
Fms-like tyrosine kinase 3 ligand (Flt-3 Ligand, or FLT3L) is an alpha-helical cytokine that regulates hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells (including dendritic cells, NK cells, and B cells) through binding to the Flt3 receptor (Flt3/Flk-2) and activating the STAT3 signaling pathway. It is expressed as a noncovalently-linked dimer by T cells and bone marrow/thymic fibroblasts and exists in both transmembrane and soluble forms. FLT3L synergizes with other cytokines (e.g., IL-3, GM-CSF, SCF, IL-2, IL-6, IL-7, and IL-15) to enhance hematopoietic cell mobilization, differentiation, and immune cell development.
Recombinant human FLT3L is used in hematopoietic stem cell (HSC) culture expansion (e.g., with SCF and TPO) and dendritic cell (DC) differentiation (e.g., for immunotherapy applications). FLT3L has also been explored as an adjuvant in therapeutic vaccines (e.g., cancer and infectious disease vaccines) to enhance antigen-specific T cell responses or DC mobilization.
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