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Description
GRIA2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen GRIA2 Synonyms Glutamate receptor 2; GluR 2; AMPA selective glutamate receptor 2; GluR B; GluR K2; Glutamate receptor ionotropic; AMPA 2; GluA2; GLUR2 Immunogen Recombinant Protein Location Cell membrane Accession P42262 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, IF Reactivity Ms, Rt Positive Sample mouse brain, rat brain Predicted Reactivity Or, CyMk Purification Immunogen Affinity
Product Specification
| Host | Rabbit |
| Antigen | GRIA2 |
| Synonyms | Glutamate receptor 2; GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic; AMPA 2; GluA2; GLUR2 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P42262 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Ms, Rt |
| Positive Sample | mouse brain, rat brain |
| Predicted Reactivity | Or, CyMk |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:500 | Ms |
| IF | 1:100 | Ms, Rt |
Background
GRIA2 (Glutamate Ionotropic Receptor AMPA Type Subunit 2, formerly GluA2) is a 96-kDa, 883-aa transmembrane protein that assembles with other AMPA-receptor subunits to form calcium-impermeable, fast-desensitizing glutamate-gated cation channels critical for excitatory synaptic transmission and plasticity throughout the CNS; its unique Q/R-edited pore loop dictates low Ca²⁺ permeability, its C-tail binds PDZ scaffolds (GRIP, PICK1, NSF) to regulate surface trafficking and long-term potentiation/depression, and mutations or altered expression are linked to epilepsy, ischemic stroke damage, schizophrenia, Alzheimer’s disease and amyotrophic lateral sclerosis, making GRIA2 a key determinant of synaptic strength and neuronal survival.
Shipping Notes
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Exchange/Return Notes
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