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Description
S-RMab® Ki67 Recombinant Rabbit mAb,PBS Only (SDT-R459)Product Specification Host Rabbit Antigen Ki67 Synonyms Proliferation marker protein Ki 67, Antigen identified by monoclonal antibody Ki 67, Antigen KI 67, MKI67 Location Nucleus Accession P46013 Clone Number SDT R459 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC, IF, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | Ki67 |
| Synonyms | Proliferation marker protein Ki-67, Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, MKI67 |
| Location | Nucleus |
| Accession | P46013 |
| Clone Number | SDT-R459 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, ICC, IF, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:500 | |
| IF | 1:200 |
Background
Antigen Ki-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore, it is associated with ribosomal RNA transcription. Ki-67 was present in the nuclei of cells in the G1, S, and G2 phases of the cell division cycle as well as in mitosis. Quiescent or resting cells in the G0 phase did not express the Ki-67 antigen. Ki-67 protein was used as diagnostic tools in different types of neoplasms because it was present in all proliferating cells (normal and tumor cells) and was an excellent operational marker to determine the growth fraction of a given cell population.
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