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Description
S-RMab® MCM2 Recombinant Rabbit mAb (SDT-018-68)Product Specification Host Rabbit Antigen MCM2 Synonyms BM28, CCNL1, CDCL1, Minichromosome maintenance Immunogen Synthetic Peptide Location Nucleus Accession P49736 Clone Number SDT 018 68 Antibody Type Rabbit mAb Isotype IgG Application WB, IHC P, ICC, IF, ICFCM Reactivity Hu, Ms Purification Protein A Research Area Epigenetics Concentration 0. 5mg ml Molecular Weight 102kDa Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | MCM2 |
| Synonyms | BM28, CCNL1, CDCL1, Minichromosome maintenance |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P49736 |
| Clone Number | SDT-018-68 |
| Antibody Type | Rabbit mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Research Area | Epigenetics |
| Concentration | 0.5mg/ml |
| Molecular Weight | 102kDa |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| ICC | 1:100 | |
| WB | 1:1000 | |
| ICFCM | 1:500 | |
| IF | 1:500 |
Background
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. MCM2 forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. MCM2 is phosphorylated, and thus regulated by protein kinases CDC2 and CDC7.
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