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Description
ATF-4 Recombinant Rabbit mAb (S-471-111)Product Specification Host Rabbit Antigen ATF 4 Synonyms cAMP dependent transcription factor ATF 4; Activating transcription factor 4; Cyclic AMP responsive element binding protein 2; cAMP responsive element binding protein 2; Tax responsive enhancer element binding protein 67; CREB2; TXREB; TaxREB67 Immunogen Recombinant Protein Location Nucleus, Cytoplasm, Cell membrane Accession P18848 Clone Number S 471 111 Antibody Type Recombinant mAb Isotype
Product Specification
| Host | Rabbit |
| Antigen | ATF-4 |
| Synonyms | cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67; CREB2; TXREB; TaxREB67 |
| Immunogen | Recombinant Protein |
| Location | Nucleus, Cytoplasm, Cell membrane |
| Accession | P18848 |
| Clone Number | S-471-111 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:100 |
Background
ATF-4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. It belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. ATF4 transcription factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. ATF4 is also involved in the cannabinoid Δ9-tetrahydrocannabinol–induced apoptosis in cancer cells, by the proapoptotic role of the stress protein p8 via its upregulation of the endoplasmic reticulum stress-related genes ATF4, CHOP, and TRB3.
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Exchange/Return Notes
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4.8 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
My girls love these
My puppies love this squeeky, bouncing ball. I bought a half dozen.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 28, 2025
★★★★★ 5
Boredom Buster
Color: Green
This ball has been a boredom buster lifesaver. On the first day my 15 week golden retriever puppy played with it for a good 2 hours straight. I was nervous he would immediately get bored with it but nope, he searches for it every day. It has helped with his puppy teething, he's more likely to play with this ball than come up and use my hand/arm/clothes to teethe on. The battery lasts a good amount of time and is quick to charge but I did wish it lasted a bit longer. Overall I'm very happy. We live in a top floor apartment but the noise doesn't seem to be too bad for the neighbors. It's good quality and seems durable.
Edit: The velcro for the sleeve wears out within a couple uses. It keeps falling off. It was my puppies FAV thing about the toy because of the pull tag thing. So now it's ineffective for him. Not sure if there's a way to get a new sleeve or not.
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Reviewed in the United States on April 2, 2025
★★★★★ 5
One of the best dog toys I’ve bought off Amazon in a long time
Color: Green
My dog Rosie is a heavy tower so it is difficult to find balls she doesn’t destroy quickly. I came across this item on Amazon and it is honestly one of the best pet toys I’ve ever bought on Amazon. After a long day of work sometimes I come home and Rosie has a lot of energy. I turn this ball on fast mode and she has so much fun. I do worry about how much shaking in her mouth. I don’t wanna give her a headache, lol but there’s also a slow mode that you can press for the ball to slowly move around, but it’s a really good toy and I’m happy. I purchased it if you have a heavy tower, I wouldn’t worry about them breaking it because we’ve had it for a couple weeks now and she’s doing great.
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Reviewed in the United States on March 15, 2026
★★★★★ 4
Not indestructible, but dogs love it
Color: Green
My dog LOVES this toy. Unfortunately, she loves it so much she destroys it. I have now purchased FOUR of these, but if left unattended for 5 minutes, my American terrier breaks this apart. She loves it so much though, I keep buying replacements. This is a wonderful enrichment toy, but you must keep an eye on your toothy friend.
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Reviewed in the United States on December 29, 2025
★★★★★ 3
Engaging and Fun, But Lacks Durability for Strong-Gripped Dogs
Color: Green
The internal mechanism of this toy works very well, and the ball’s movement immediately caught the attention of my Boxer pup. He was absolutely fascinated and spent hours each day playing with it. However, while the toy’s design is engaging, the durability of the exterior leaves much to be desired—especially for dogs who tend to pick things up with a firm grip.
We didn’t know what to expect since our pup hadn’t previously played with an interactive ball, so we supervised playtime and made sure to store the ball in a safe spot when we couldn’t keep an eye on him. Despite this, the ball didn’t hold up. Our pup wasn’t intentionally chewing it. He simply carried the ball in his mouth when we moved downstairs or to another room, yet the grip while he carried the ball caused significant damage to the exterior. Within about a week of regular use (approximately 40 hours in total), the ball’s outer layer became deeply gouged by his teeth.
To clarify, my pup wasn’t biting down hard or trying to destroy it, but his natural grip while carrying the ball left deep grooves in the surface. In just days, these gouges made the exterior sharp to the touch and compromised the structure. By the end of the week, we couldn’t screw the cover back together after removing it to recharge the ball, which made it unusable. And I was dismayed that there aren’t replacements readily available.
Overall, my pup absolutely loved this toy — it was engaging and kept him entertained for hours. However, if your dog has a strong grip or frequently carries toys in their mouth, this may not hold up as well as expected. It’s a great concept but needs a more durable outer layer and replacement hard covers to make it a long-term investment.
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Reviewed in the United States on January 3, 2025
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