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Description
IL-21 Protein, HumanProduct Specification Species Human Antigen IL 21 Synonyms Interleukin 21; IL 21; Za11 Accession Q9HBE4 Amino Acid Sequence Gln32 Ser162 Expression System E. coli Molecular Weight 17 18 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 50mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Antigen | IL-21 |
| Synonyms | Interleukin-21; IL-21; Za11 |
| Accession | Q9HBE4 |
| Amino Acid Sequence | Gln32-Ser162 |
| Expression System | E.coli |
| Molecular Weight | 17-18 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 50mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Blood. 2007 May 15;109(10):4135-42. |
Background
IL-21 (another common gamma chain cytokine) that is produced primarily by CD4+ T cells of the TFH lineage has a range of functions, including the promotion of apoptosis, proliferation, and gain of effector function in B cells, T cells, NK cells, and DC. After BMT, TFH cells drive marginal zone B cell expansion and aberrant B cell development. These B cells produce alloantibodies in a Bruton's tyrosine kinase (BTK)–dependent manner, and these antibodies are now established as making a critical contribution to cGVHD. IL-21 also induces IL-10 production and can thus have both regulatory and proinflammatory roles, depending on the other cytokines present. IL-21R deficient animals and specific blocking antibodies have been used to assess the role of IL-21 in GVHD, confirming it has a pathogenic role in the GI tract (with receptor-deficient animals experiencing less GI-specific GVHD). The use of IL-21 blocking mAb used in a xenogeneic mouse model (with NOD/SCID/γc−/- recipients) has demonstrated a decrease in CD8+ T cells and an increased proportion of Tregs. This group also demonstrated local protein expression of IL-21 in the GIT and skin, but not serum. Neutralization of IL-21 represents a promising therapeutic strategy to prevent and treat cGVHD that now requires investigation in a clinical study.
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