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Description
Connexin 43/GJA1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Connexin 43 GJA1 Synonyms Gap junction alpha 1 protein; Connexin 43 (Cx43); Gap junction 43 kDa heart protein; GJAL Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum Accession P17302 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample HEK 293, mouse cardiac muscle, rat cardiac muscle Predicted Reactivity Dg, AfGrMk, Rb, CyMk, Pg,
Product Specification
| Host | Rabbit |
| Antigen | Connexin 43/GJA1 |
| Synonyms | Gap junction alpha-1 protein; Connexin-43 (Cx43); Gap junction 43 kDa heart protein; GJAL |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum |
| Accession | P17302 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, mouse cardiac muscle, rat cardiac muscle |
| Predicted Reactivity | Dg, AfGrMk, Rb, CyMk, Pg, Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu, Ms, Rat |
| IF | 1:500 | Ms, Rat |
Background
Connexin 43 (Cx43), also known as GJA1, is the predominant gap junction protein in vertebrates, encoded by the GJA1 gene. It assembles into hexameric structures in the Golgi apparatus and translocates to the plasma membrane to form gap junction channels, facilitating intercellular communication by allowing the rapid transmission of ions and small molecules between adjacent cells. Cx43 is widely expressed in various tissues, including the heart, where it plays a crucial role in cardiac function and protection against arrhythmias. In addition to its canonical role in gap junction formation, Cx43 has been implicated in non-canonical functions such as cell proliferation, tumor suppression, and stress response. For example, the alternatively translated isoform GJA1-20k protects Cx43 from degradation, stabilizes actin, and mediates ischemic preconditioning. Dysregulation of Cx43 expression is associated with various diseases, including cardiac arrhythmias, cancer, and neurodegenerative disorders.
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