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Description
B7-2/CD86 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms rHuB7 2; Activation B7 2 antigen; B70; BU63; CD28LG2 Accession Q549Q9 Amino Acid Sequence Val24 Glu245, with C terminal Fc Expression System HEK293 Molecular Weight 65 75kDa (Reducing) Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to
Product Specification
| Species | Mouse |
| Synonyms | rHuB7-2; Activation B7-2 antigen; B70; BU63; CD28LG2 |
| Accession | Q549Q9 |
| Amino Acid Sequence | Val24-Glu245, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 65-75kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Chia-Lin Chen, Jeffrey Y. Huang, Chun-HsiangWang, Stanley M Tahara, Lin Zhou, Yasuteru Kondo, Joel Schechter, Lishan Su,Michael M C. Lai, Takaji Wakita, François-Loïc Cosset, Jae U Jung & KeigoMachida: Hepatitis C virus has a genetically determined lymphotropism throughco-receptor B7.2, NatureCommunications volume 8, Article number: 13882 (2017). |
Background
CD86, also known as B-lymphocyte activation antigen B7-2 (formerly referred to as B70), is a member of the cell surface immunoglobulin superfamily. Predominantly existing as a monomer on cell surfaces, B7-2 interacts with two co-stimulatory receptors: CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which are expressed on T cells. This interaction initiates signal pathways that regulate T cell activation and tolerance, cytokine production, and the generation of cytotoxic T lymphocytes (CTLs). B7 family members are transmembrane cell surface molecules that play crucial roles in immune activation and the maintenance of immune tolerance.
B7-2 is highly expressed on activated antigen-presenting cells (APCs), such as B cells, dendritic cells, and monocytes, as well as on vascular endothelial cells. B7-2 and its closely related counterpart, B7-1/CD80, exhibit overlapping yet distinct functional characteristics.
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