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Description
AKT2 Recombinant Rabbit mAb (S-2617-6)Product Specification Host Rabbit Antigen AKT2 Synonyms RAC beta serine threonine protein kinase; Protein kinase Akt 2; Protein kinase B beta (PKB beta); RAC protein kinase beta (RAC PK beta) Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P31751 Clone Number S 2617 6 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, MCF7, HepG2, A549, Jurkat, 293T, NIH 3T3, Neuro 2a,
Product Specification
| Host | Rabbit |
| Antigen | AKT2 |
| Synonyms | RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta (PKB beta); RAC protein kinase beta (RAC-PK-beta) |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P31751 |
| Clone Number | S-2617-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, MCF7, HepG2, A549, Jurkat, 293T, NIH/3T3, Neuro-2a, C2C12, mouse brain, mouse heart, mouse spleen, PC-12, C6, rat brain, rat heart, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
AKT2 (also known as Protein Kinase B β, PKBβ) is a 481-residue serine/threonine kinase ubiquitously expressed but enriched in insulin-responsive tissues, where it transduces signals from the PI3K pathway through dual phosphorylation at T309 by PDK1 and S474 by mTORC2 to adopt an active conformation that phosphorylates >100 substrates—key among them GSK3β, FOXO1, AS160, and mTOR—thereby orchestrating glucose uptake via GLUT4 translocation, glycogen synthesis, cell survival, proliferation, and lipid metabolism; its dysregulation through activating E17K mutations, amplifications, or loss of PTEN contributes to type 2 diabetes, metabolic syndrome, and multiple cancers, making AKT2 a pivotal therapeutic target for isoform-selective inhibitors and metabolic modulators.
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