SKU: 2845771231

Carbonic Anhydrase IX/CA9 His Tag Protein, Cynomolgus

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Description

Carbonic Anhydrase IX/CA9 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA IX; CAIX), Membrane antigen MN, P54 58N Accession A0A2K5VQG9 Amino Acid Sequence Gln38 Leu398, with C terminal His Expression System HEK293 Molecular Weight 40 50 kDa (Reducing) Purity 95% by SDS PAGE &95% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, pH7.

Product Specification


Species Cynomolgus
Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX), Membrane antigen MN, P54/58N
Accession A0A2K5VQG9
Amino Acid Sequence Gln38-Leu398, with C-terminal His
Expression System HEK293
Molecular Weight

40-50 kDa (Reducing)

Purity >95% by SDS-PAGE &>95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, pH7.4,
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008; 7:168-81.
McDonald PC, Swayampakula M, Dedhar S. Coordinated regulation of metabolic transporters and migration/invasion by carbonic anhydrase IX. Metabolites 2018;8: E20.

Background

The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of amino acid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.

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SKU: 2845771231

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Amazon Customer
Cuba, US
★★★★★ 3
It was alright
Format: Kindle
Pervious to this book, I had no knowledge of the struggles of the Chinese in the South during the post Civil War era. For that reason, I'm glad I read this book. I enjoyed that this book discussed and gave perspective on many social issues of that time. The main character is spunky and likable. There are many unbelievable scenes and conversations that I did not enjoy because they seemed too far-fetched. Why the author had to include a description of a naked man was also not to my liking. Worst of all, though, was the incredible number of similes in this book. There were just too many, and it got annoying. Overall, it was good enough to read, but I do not highly recommend it.
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Reviewed in the United States on August 19, 2023
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R. Kretchman
Draper, US
★★★★★ 5
A Chinese in Atlanta
Format: Kindle
The Girl Downstairs was a charming book. Although the writing isn’t particularly sophisticated, it felt like Jo was letting us peek into the pages of her diary—raw, honest, and deeply personal. Her journey, as the main character, was both heartwarming and heartbreaking. Through her eyes, we witness the simple beauty of connection and the ugly truth of prejudice that has plagued our country for far too long. It’s a powerful reminder that humanity should never be measured by the color of one’s skin. This is another great YA read—I highly recommend it.
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Reviewed in the United States on June 15, 2025
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C. Wong
Natrona Heights, US
★★★★★ 5
Atlanta During the 1890's
Format: Paperback
Whether you like The Downstairs Girl or not depends on what you crave. If you crave historical fiction that will teach you, or that helps you realize the myriad of things that were going on in a certian place and time (Atlanta during the 1890s, or an imaginative author who never use trite metaphors or similes, you will love this book. Or if you want to quickly turn pages, you will be disappointed. If you want a simple plot, do not read this book. If you want an intricately spun story with plenty of mystrey, humor and many surprises, you will love it. Jo Kuan is a Chinese American without voting rights, deStined to be a servang and doesn;t knw who her mother or father are, lives in a basement of a family with Old Gin who she thinks of as old man who adopted not offically but out of love. Chinese Americans were brought into the South after the Civil War to take over what slaves used to do but instead of no pay, they got tiny pay. You could walk or take a streetcar to work. Blacks sat the back of the streetcars, but if you were Chinese American, you didn't know where you sat or were told to gat off. They could not own or rent, where were you supposed to live; It was the start of Jim Crow laws and of cocoa cola. Women suffragettes started working towards the vote of white women. This was not a quiet oeriod of history. I thoroughly enjoyed this peak at Atlanta in the 1890's through an Asian American young woman's eyes, ears and even her nose.
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Reviewed in the United States on May 9, 2022
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Oscar Ibarra
San Leandro, US
★★★★★ 5
simple to read and very helpful
Format: Kindle
Thank you, Mr. McLean for taking the time to write this book, it truly is helpful in our current situation in Las Vegas, NV.
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Reviewed in the United States on March 24, 2022
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Kindle Customer
Omaha, US
★★★★★ 5
Recommended reading for whoever is/will applying to section 8
Format: Kindle
Good advices for those who need the government assistance. Very interesting and creative ways to successfully be granted with your vouch with the program. Thanks Mike! Well done!
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Reviewed in the United States on March 21, 2021

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