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Description
RanBP2 Recombinant Rabbit mAb (S-2593-310)Product Specification Host Rabbit Antigen RanBP2 Synonyms E3 SUMO protein ligase RanBP2; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran binding protein 2 (RanBP2); p270; NUP358; RANBP2 Immunogen Recombinant Protein Location Nucleus Accession P49792 Clone Number S 2593 310 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, 293T, SH SY5Y Predicted Reactivity Cz
Product Specification
| Host | Rabbit |
| Antigen | RanBP2 |
| Synonyms | E3 SUMO-protein ligase RanBP2; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2 (RanBP2); p270; NUP358; RANBP2 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P49792 |
| Clone Number | S-2593-310 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, 293T, SH-SY5Y |
| Predicted Reactivity | Cz |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
RanBP2, a 358-kDa nucleoporin that forms the cytoplasmic filaments of the nuclear pore complex, functions as an E3 SUMO ligase and a scaffold for RanGAP1-SUMO1-Ubc9 complexes, thereby orchestrating nucleocytoplasmic transport, mitotic spindle assembly, and the recruitment of kinesin-1 to drive plus-end-directed motility of aggresomes and lipid droplets while also regulating NF-κB signaling, circadian rhythms, and neuronal responses through its extensive network of interactions at the pore and beyond.
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