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Description
ISL2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen ISL2 Synonyms Insulin gene enhancer protein ISL 2; Islet 2 Immunogen Synthetic Peptide Location Nucleus Accession Q96A47 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HUVEC, HeLa, 293T Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | ISL2 |
| Synonyms | Insulin gene enhancer protein ISL-2; Islet-2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q96A47 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HUVEC, HeLa, 293T |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
Islet-2 (ISL2) is a LIM/homeodomain-type transcription factor that plays a crucial role in various developmental processes, particularly in the nervous system and pancreas. It is expressed in embryonic zebrafish and is involved in the differentiation of neurons and the regulation of gene expression. ISL2 is also implicated in the regulation of metabolic pathways and immune responses, and its expression is associated with diseases such as Fraser Syndrome 1 and AMME Complex. In pancreatic islets, ISL2 has been shown to be involved in the regulation of insulin secretion and β-cell function. Additionally, ISL2 has been identified as a potential tumor suppressor in pancreatic cancer, where its epigenetic silencing can reprogram the metabolism of cancer cells, leading to increased oxidative phosphorylation and sensitivity to mitochondrial complex I inhibitors.
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