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Description
Mouse Anti-Rat CD86 Antibody (S-R580)Product Specification Host Mouse Antigen CD86 Location Cell membrane Accession A6IRC2 Clone Number S R580 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes treated 4h with 10g ml LPS Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied.
Product Specification
| Host | Mouse |
| Antigen | CD86 |
| Location | Cell membrane |
| Accession | A6IRC2 |
| Clone Number | S-R580 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes treated 4h with 10μg/ml LPS |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Rt |
Background
CD86, also known as B7-2, is a 70 kDa glycoprotein and a type I membrane protein that belongs to the immunoglobulin superfamily. It is primarily expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. CD86 serves as a ligand for two T cell surface proteins: CD28 and CTLA-4. The interaction between CD86 and CD28 provides a crucial co-stimulatory signal for T cell activation and survival, while binding to CTLA-4 negatively regulates T cell activation, thereby dampening the immune response. Additionally, CD86 plays a role in B cell function regulation and can influence IgG1 production. It is rapidly upregulated on B cells upon activation and can be induced on monocytes by interferon-gamma. CD86 is also involved in various immune processes, including the activation of the NF-kappa-B signaling pathway and the regulation of cytokine production.
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4.7 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 4
Good history, but not fun, engaging in popular literature.
Format: Paperback
The author is a very competent historian, and proves her points. She does so by stating each thesis and then reciting an exceedingly long string of supporting examples. Rinse and repeat. This is high quality, academic style history, but it’s not very engaging as popular literature. No one’s going to say “I couldn’t put it down.” That being said - I liked it! I learned a lot. Thanks.
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Reviewed in the United States on March 1, 2023
★★★★★ 5
Should be required
Format: Paperback
In my opinion, this book should be required reading in high school/college history classes. It’s so important to learn accurate history when it comes to slavery and this book does that. White women played a larger role than we are taught. Please give this a read!
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Reviewed in the United States on October 23, 2025
★★★★★ 5
No regets
Format: Paperback
This was a good book to read! In school you only learn the male prospective during slavery! I know feel I can say white woman played a major role during slavery times. I like that fact that the Author put in the information to where we can go srwcah and read for ourselves. The visuals where an added touch. I feel like because alot of women of that time couldn't write so alot of information was missing. I feel like this is a must read.
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Reviewed in the United States on April 9, 2025
★★★★★ 5
One of the most poignant books I have read in a long time.
Format: Paperback
One of the most poignant books I have read in a long time.
“Southern communities, lawmakers, and courts recognized slave-owning women as individuals able to acquire and exercise mastery over enslaved people, s is evident from laws passed throughout the South. Laws dating back to the colonial period routinely recognized the mistresses owned enslaved people in their own right, and these same laws acknowledged the fact that these women were capable of exercising mastery over the enslaved people they owned.” Stephanie E. Jones - Rogers.
They were referred to as Southern Belles’. Revered for their ladylike daintiness. But… there was nothing dainty about their dealings for they too, owned human property. These white southern mistresses were heavily involved and often owned more property than their male counterparts even being the breadwinners. These women were barbaric and wore the crown of cruelty.
Dr. Rogers gave the enslaved a voice in this text – allowing our ancestors to share with us their story and experiences under the thumb of white mistresses. This text uncovers the extent of the involvement that white women had with slave ownership. There was discord in marriages due to white women struggles to maintain control of their financial gains of human property. These women utilized the judicial system to protect their pecuniary interests. The parents of these white girls/women bequeathed slaves to white females i.e. as young as newborns – which leads us to mistresses in the making – that is the education of young white women of the mastery of slave ownership. My heart broke as I was able to envision the accounts of atrocities inflicted upon our ancestors. Our people were raped and forced into being breeders and wet nurses to ensure the livelihood of these white mistresses and their families. The evidence is insurmountable in all the ways slave-owning women invested in, and profited from their financial ties to American slavery and its marketplace. Most importantly, there was testimony from formerly enslaved people of their experiences within slavery. This text is a mandatory read for all and in my opinion, must be included as part of the curriculum in schools.
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Reviewed in the United States on October 16, 2020
★★★★★ 5
Slave Trade was not only a White Man's Affair
Format: Kindle
The book is an excellent read particularly in today's climate. Why 53% of white women would put a vile man in office is explained in the pages of this book. White women held positions of power in the America slave trade, a fact overlooked in history. These southern bell's represented as the gold standard of woman hood in the antebellum south were anything but, and they for the most part showed as much, business savvy as down right cruelty in the slave trade. They benefited in every conceivable way from this free labor market. They were no advocates for the kind humane treatment of slaves. In many cases they were as vicious as their counterpart and just as committed to a keeping Blacks marred in the system of bondage. They are in most cases depicted as silent partners and where that might be the case many white women had full command and knowledge of the value of a slave they invested in and they wanted a hefty return. In fact they used every means on the table to keep these black, men, women and children bound to their wealth creation. These co-conspirators had more than a hand in the cookie jar, they enjoyed the power and did not hesitate to support the maintenance of this inhumane institution.
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Reviewed in the United States on April 24, 2019