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Description
GH Recombinant Rabbit mAb (SDT-234-92)Product Specification Host Rabbit Antigen GH Synonyms Somatotropin; Growth hormone (GH; GH N); Growth hormone 1; Pituitary growth hormone; GH1 Immunogen Recombinant Protein Accession P01241 Clone Number SDT 234 92 Antibody Type Recombinant mAb Isotype IgG Application CLIA, Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against IGFBP3, IGF 1, FSH, hCG, LH, PRL, TSH Purification Protein A Concentration 2 mg ml Purity >95% by HPLC
Product Specification
| Host | Rabbit |
| Antigen | GH |
| Synonyms | Somatotropin; Growth hormone (GH; GH-N); Growth hormone 1; Pituitary growth hormone; GH1 |
| Immunogen | Recombinant Protein |
| Accession | P01241 |
| Clone Number | SDT-234-92 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against IGFBP3, IGF-1, FSH, hCG, LH, PRL, TSH |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Growth hormone is synthesized primarily by somatotropin in the anterior pituitary and stored in secretory granules. GH is a pleiotropic cytokine that exerts its biological effects by binding to transmembrane GH receptors present in many cell types. hGH stimulates hepatic insulin-like growth factor-1 and mobilizes fatty acids from fat deposits to the liver. GH can act directly or indirectly through IGF-1 on B cells, T cells, NK cells, macrophages, and neutrophils to exert immunomodulatory activity. Insufficient secretion of hGH results in dwarfism in children, and excessive secretion results in gigantism in children or acromegaly in adults.
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Exchange/Return Notes
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